Molecular targeting therapy for pancreatic cancer: current knowledge and perspectives from bench to bedside

被引：38
|
作者：
Furukawa, Toru [1 ]
机构：
[1] Tokyo Womens Med Univ, Int Res & Educ Inst Integrated Med Sci, Shinjuku Ku, Tokyo 1628666, Japan
来源：
JOURNAL OF GASTROENTEROLOGY | 2008年 / 43卷 / 12期
关键词：
pancreatic cancer; molecular targeting; RAS-MAPK; PI3K-AKT; hedgehog;
D O I：
10.1007/s00535-008-2226-1
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Current medical interventions for pancreatic cancer are insufficient. Recent molecular investigations have elucidated complex genetic mechanisms of cancer that especially involve multiple signal transduction pathways; this enables us to develop molecular medicines targeting specific genetic molecules in the pathways. These molecular medicines seem to promise clues for curing cancers, including pancreatic cancer. This review describes current knowledge and perspectives regarding the development of molecular medicines for pancreatic cancer by focusing on growth factor receptor systems and three major signal transduction pathways: the RAS-MAPK, PI3K-AKT-mTOR, and hedgehog pathways.
引用
收藏
页码：905 / 911
页数：7
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