Synthesis and in Vitro Cytotoxic Activity of Some New Colchicine Analogues

被引：0

作者：

Wang, Jian Sen ^{[1
]}

Wang, Bo ^{[1
]}

Li, Hong Yu ^{[1
]}

Shen, Li Hong ^{[1
]}

Zhang, Xu ^{[2
]}

Liu, Li Jie ^{[3
]}

机构：

[1] Handan Coll, Handan Key Lab Organ Small Mol Mat, Handan 056005, Hebei Province, Peoples R China

[2] Handan Coll, Dept Chem, Handan 056005, Hebei Province, Peoples R China

[3] Hebei YiLing Acad Med, Shijiazhuang 050035, Hebei Province, Peoples R China

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 14期

关键词：

Colchicine; Nitrates; Cytotoxic activity; ANTICANCER AGENTS; DERIVATIVES; TUBULIN; CANCER; DESIGN; ACID; NO;

D O I：

10.14233/ajchem.2013.15072

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new colchicine analogues (6a-f,8a-b) were synthesized by coupling nitrates with C-7 and replacement of the 10-methoxy with N(CH3)(2) in order to determine their cytotoxic activity. The compounds were synthesized in good yield and the structures of all newly synthesized compounds were established on the basis of their IR, H-1 NMR and elemental analysis. The synthesized compounds were tested in vitro antitumor activity against four human cancer cell lines by MTT assay. It was found that many of the derivatives displayed significant activity, particularly, compound 6c showed more potent cytotoxic activities than colchicine.

引用

页码：8072 / 8074

页数：3

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