Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment

被引:0
|
作者
van Hooren, Luuk
Georganaki, Maria
Huang, Hua
Mangsbo, Sara
Dimberg, Anna
机构
关键词
D O I
10.1158/1538-7445.AM2016-1485
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1485
引用
收藏
页数:3
相关论文
共 50 条
  • [41] A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell-Mediated Antitumor Responses in Human B-cell Malignancies
    de Weerdt, Iris
    Lameris, Roeland
    Scheffer, George L.
    Vree, Jana
    de Boer, Renate
    Stam, Anita G.
    van de Ven, Rieneke
    Levin, Mark-David
    Pals, Steven T.
    Roovers, Rob C.
    Parren, Paul W. H., I
    de Gruijl, Tanja D.
    Kater, Arnon P.
    van der Vliet, Hans J.
    CANCER IMMUNOLOGY RESEARCH, 2021, 9 (01) : 50 - 61
  • [42] CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76 (vol 26, pg 6727, 2016)
    Hassan, Namir J.
    Simmonds, Stephen J.
    Clarkson, Nicholas G.
    Hanrahan, Sarah
    Puklavec, Michael J.
    Bomb, Martine
    Barclay, A. Neil
    Brown, Marion H.
    MOLECULAR AND CELLULAR BIOLOGY, 2019, 39 (07)
  • [43] CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76 (vol 26, pg 6727, 2006)
    Hassan, Namir J.
    Simmonds, Stephen J.
    Clarkson, Nicholas G.
    Hanrahan, Sarah
    Puklavec, Michael J.
    Bomb, Martine
    Barclay, A. Neil
    Brown, Marion H.
    MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (12) : 3452 - 3452
  • [44] Single Domain Antibody-Mediated Blockade of Programmed Death-Ligand 1 on Dendritic Cells Enhances CD8 T-cell Activation and Cytokine Production
    Broos, Katrijn
    Lecocq, Quentin
    De Keersmaecker, Brenda
    Raes, Geert
    Corthals, Jurgen
    Lion, Eva
    Thielemans, Kris
    Devoogdt, Nick
    Keyaerts, Marleen
    Breckpot, Karine
    VACCINES, 2019, 7 (03)
  • [45] Pre-Activation of Toll-Like Receptor 2 Enhances CD8+ T-Cell Responses and Accelerates Hepatitis B Virus Clearance in the Mouse Models
    Lin, Yong
    Huang, Xuan
    Wu, Jun
    Liu, Jia
    Chen, Mingfa
    Ma, Zhiyong
    Zhang, Ejuan
    Liu, Yan
    Huang, Shunmei
    Li, Qian
    Zhang, Xiaoyong
    Hou, Jinlin
    Yang, Dongliang
    Lu, Mengji
    Xu, Yang
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [46] An agonist antibody specific for CD40 induces dendritic cell maturation and promotes autologous anti-tumour T-cell responses in an in vitro mixed autologous tumour cell/lymph node cell model
    Hunter, T. B.
    Alsarraj, M.
    Gladue, R. P.
    Bedian, V.
    Antonia, S. J.
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2007, 65 (05) : 479 - 486
  • [47] TGF-Beta treatment modulates PD-L1 and CD40 expression in proximal renal tubular epithelial cells and enhances CD8+ cytotoxic T-Cell responses
    Starke, Astrid
    Wuethrich, Rudolf P.
    Waeckerle-Men, Ying
    NEPHRON EXPERIMENTAL NEPHROLOGY, 2007, 107 (01): : E22 - E29
  • [48] CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation
    Brandao, JG
    Scheper, RJ
    Lougheed, SM
    Curiel, DT
    Tillman, BW
    Gerritsen, WR
    van den Eertwegh, AJM
    Pinedo, HM
    Haisma, HJ
    de Gruijl, TD
    VACCINE, 2003, 21 (19-20) : 2268 - 2272
  • [49] CTLA4 blockade maximizes antitumor T-cell activation by dendritic cells presenting idiotype protein or opsonized anti-CD20 antibody-coated lymphoma cells
    Hsu, FJ
    Komarovskaya, M
    JOURNAL OF IMMUNOTHERAPY, 2002, 25 (06) : 455 - 468
  • [50] Antibody association with HER-2/neu-targeted vaccine enhances CD8+ T cell responses in mice through Fc-mediated activation of DCs
    Kim, Peter S.
    Armstrong, Todd D.
    Song, Hong
    Wolpoe, Matthew E.
    Weiss, Vivian
    Manning, Elizabeth A.
    Huang, Lan Qing
    Murata, Satoshi
    Sgouros, George
    Emens, Leisha A.
    Reilly, R. Todd
    Jaffee, Elizabeth M.
    JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (05): : 1700 - 1711