Ultrasmall Biocompatible Bi2Se3 Nanodots for Multimodal Imaging-Guided Synergistic Radiophotothermal Therapy against Cancer

被引：206
|
作者：
Mao, Fangxin [1 ,2 ]
Wen, Ling [1 ]
Sun, Caixia [1 ]
Zhang, Shaohua [1 ]
Wang, Guanglin [1 ]
Zeng, Jianfeng [1 ]
Wang, Yong [1 ]
Ma, Jianmin [2 ]
Gao, Mingyuan [1 ]
Li, Zhen [1 ]
机构：
[1] Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Ctr Mol Imaging & Nucl Med, Collaborat Innovat Ctr Radiat Med,Jiangsu Higher, Suzhou 215123, Peoples R China
[2] Hunan Univ, Sch Phys & Elect, Changsha 410082, Hunan, Peoples R China
来源：
ACS NANO | 2016年 / 10卷 / 12期
基金：
中国国家自然科学基金;
关键词：
multimodal imaging; radiophotothermal therapy; bismuth selenide nanodots; ultrasmall; bovine serum albumin; PHOTOTHERMAL THERAPY; INORGANIC NANOPARTICLES; TOPOLOGICAL INSULATOR; COUNTER ELECTRODES; SCALABLE SYNTHESIS; FACILE SYNTHESIS; CATION-EXCHANGE; BISMUTH; NANOMATERIALS; RADIOTHERAPY;
D O I：
10.1021/acsnano.6b06067
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sub-3 nm ultrasmall Bi2Se3 nanodots stabilized with bovine serum albumin were successfully synthesized through a reaction of hydroxyethylthioselenide with bismuth chloride in aqueous solution under ambient conditions. These nanodots exhibit a high photothermal conversion efficiency (eta = 50.7%) due to their strong broad absorbance in the near-infrared (NIR) window and serve as a nanotheranostic agent for photoacoustic imaging and photothermal cancer therapy. In addition, they also display radioenhancement with a ratio of 6% due to their sensitivity to X-rays, which makes them a potential sensitizer for radiotherapy. These nanodots were also labled with radioactive Tc-99m for quantification of their biodistribution by single-photon-emission computed tomography (SPECT)/computed tomography (CT) imaging. Our work demonstrates the potential of ultrasmall Bi2Se3 nanodots in multimodal imaging-guided synergetic radiophotothermal therapy of cancer.
引用
收藏
页码：11145 / 11155
页数：11
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