The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis

被引：28
|
作者：
Garcia, Samuel [1 ,2 ]
Conde, Carmen [3 ]
机构：
[1] Univ Med Ctr, Lab Translat Immunol, NL-3508 GA Utrecht, Netherlands
[2] Univ Med Ctr, Dept Rheumatol & Clin Immunol, NL-3508 GA Utrecht, Netherlands
[3] Hosp Clin Univ Santiago de Compostela CHUS, SERGAS, IDIS, Lab Invest 8, Santiago De Compostela 15706, Spain
来源：
MEDIATORS OF INFLAMMATION | 2015年 / 2015卷
关键词：
COLLAGEN-INDUCED ARTHRITIS; ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; APOPTOSIS-INDUCING FACTOR; ADP-RIBOSE POLYMERASE-1; TUMOR-NECROSIS-FACTOR; NECROTIC CELL-DEATH; PARP INHIBITORS; INFLAMMATORY ARTHRITIS; DEFICIENT MICE;
D O I：
10.1155/2015/837250
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer. In these diseases, the pharmacological inhibition of PARP-1 has shown a beneficial effect, suggesting that PARP-1 regulates their inflammatory processes. In recent years, we have studied the role of PARP-1 in rheumatoid arthritis, as have other researchers, and the results have shown that PARP-1 has an important function in the development of this disease. This review summarizes current knowledge on the effects of PARP-1 in rheumatoid arthritis.
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页数：8
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