Recent advances in understanding Crohn's disease

被引：10
|
作者：
Di Sabatino, Antonio [1 ,3 ]
Rovedatti, Laura [1 ]
Vidali, Francesca [1 ]
MacDonald, Thomas Thornton [2 ]
Corazza, Gino Roberto [1 ]
机构：
[1] Univ Pavia, Fdn IRCCS Policlin S Matteo, Dept Med 1, Ctr Studio & Cura Malattie Infiammatorie Croniche, Pavia, Italy
[2] Barts & London Queen Marys Sch Med & Dent, Blizard Inst Cell & Mol Sci, Ctr Immunol & Infect Dis, London, England
[3] Fdn IRCCS Policlin San Matteo, Clin Med 1, I-27100 Pavia, Italy
来源：
INTERNAL AND EMERGENCY MEDICINE | 2013年 / 8卷 / 02期
关键词：
Chronic inflammation; Fistula; Inflammatory bowel disease; Stricture; Therapy; INFLAMMATORY-BOWEL-DISEASE; TUMOR-NECROSIS-FACTOR; METAANALYSIS; SUSCEPTIBILITY; INFLIXIMAB; THERAPY; EPIDEMIOLOGY; MAINTENANCE; ANTAGONISTS; ANTIBODIES;
D O I：
10.1007/s11739-011-0599-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Crohn's disease is a chronic inflammatory bowel disorder resulting from an inappropriate innate and acquired immune response to commensal microorganisms in genetically susceptible individuals. This disease has a fluctuating course, with alternating periods of remission and relapses, and it is characterized by a remarkable clinical heterogeneity; it may be complicated by perianal fistulas, abscesses, and intestinal strictures leading to obstructions, besides several systemic manifestations. However, a complete resolution of the disease is currently not possible, yet Crohn's disease can be managed with established and novel therapies, which achieve long-term remission and acceptable quality of life. This review is focused on novel advances in basic and clinical aspects of Crohn's disease, although it also deals with new trends in diagnosis and treatment.
引用
收藏
页码：101 / 113
页数：13
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