user

Recent advances in understanding Crohn's disease

被引：10
|
作者：
Di Sabatino, Antonio [1 ,3 ]
Rovedatti, Laura [1 ]
Vidali, Francesca [1 ]
MacDonald, Thomas Thornton [2 ]
Corazza, Gino Roberto [1 ]
机构：
[1] Univ Pavia, Fdn IRCCS Policlin S Matteo, Dept Med 1, Ctr Studio & Cura Malattie Infiammatorie Croniche, Pavia, Italy
[2] Barts & London Queen Marys Sch Med & Dent, Blizard Inst Cell & Mol Sci, Ctr Immunol & Infect Dis, London, England
[3] Fdn IRCCS Policlin San Matteo, Clin Med 1, I-27100 Pavia, Italy
来源：
INTERNAL AND EMERGENCY MEDICINE | 2013年 / 8卷 / 02期
关键词：
Chronic inflammation; Fistula; Inflammatory bowel disease; Stricture; Therapy; INFLAMMATORY-BOWEL-DISEASE; TUMOR-NECROSIS-FACTOR; METAANALYSIS; SUSCEPTIBILITY; INFLIXIMAB; THERAPY; EPIDEMIOLOGY; MAINTENANCE; ANTAGONISTS; ANTIBODIES;
D O I：
10.1007/s11739-011-0599-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Crohn's disease is a chronic inflammatory bowel disorder resulting from an inappropriate innate and acquired immune response to commensal microorganisms in genetically susceptible individuals. This disease has a fluctuating course, with alternating periods of remission and relapses, and it is characterized by a remarkable clinical heterogeneity; it may be complicated by perianal fistulas, abscesses, and intestinal strictures leading to obstructions, besides several systemic manifestations. However, a complete resolution of the disease is currently not possible, yet Crohn's disease can be managed with established and novel therapies, which achieve long-term remission and acceptable quality of life. This review is focused on novel advances in basic and clinical aspects of Crohn's disease, although it also deals with new trends in diagnosis and treatment.
引用
收藏
页码：101 / 113
页数：13
相关论文
共 50 条
  • [1] Recent advances in understanding Crohn’s disease
    Antonio Di Sabatino
    Laura Rovedatti
    Francesca Vidali
    Thomas Thornton MacDonald
    Gino Roberto Corazza
    [J]. Internal and Emergency Medicine, 2013, 8 : 101 - 113
  • [2] Recent advances in the management of Crohn's disease
    Caprilli, R.
    Angelucci, E.
    Clemente, V.
    [J]. DIGESTIVE AND LIVER DISEASE, 2008, 40 (09) : 709 - 716
  • [3] Recent advances in the use of ultrasound in Crohn's disease
    Barchi, Alberto
    D'Amico, Ferdinando
    Zilli, Alessandra
    Furfaro, Federica
    Parigi, Tommaso Lorenzo
    Fiorino, Gionata
    Peyrin-Biroulet, Laurent
    Danese, Silvio
    Dal Buono, Arianna
    Allocca, Mariangela
    [J]. EXPERT REVIEW OF MEDICAL DEVICES, 2023, 20 (12) : 1119 - 1129
  • [4] Molecular genetics of Crohn's disease: Recent advances
    Satsangi, J
    Parkes, M
    Jewell, DP
    [J]. EUROPEAN JOURNAL OF SURGERY, 1998, 164 (12) : 887 - 891
  • [5] Recent advances in the medical therapy of Crohn's disease in childhood
    Bremner, A. R.
    Beattie, R. M.
    [J]. EXPERT OPINION ON PHARMACOTHERAPY, 2007, 8 (15) : 2553 - 2568
  • [6] Recent advances in understanding the pathogenesis of Huntington's disease
    Reddy, PH
    Williams, M
    Tagle, DA
    [J]. TRENDS IN NEUROSCIENCES, 1999, 22 (06) : 248 - 255
  • [7] Recent advances in the etiology of Crohn's disease.: Environment and genetics
    Colombel, JF
    Louvet, B
    Müller-Alouf, H
    Desreumaux, P
    [J]. RECENT ADVANCES IN THE PATHOPHYSIOLOGY OF GASTRO-INTESTINAL AND LIVER DISEASES, 1997, : 109 - 131
  • [8] Recent advances in treatment of anal diseases (Crohn's disease excluded)
    Siproudhis, L
    [J]. GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE, 2001, 25 (04): : B101 - B109
  • [9] Perspectives on recent advances in the understanding and treatment of Parkinson's disease
    Schapira, A. H.
    Agid, Y.
    Barone, P.
    Jenner, P.
    Lemke, M. R.
    Poewe, W.
    Rascol, O.
    Reichmann, H.
    Tolosa, E.
    [J]. EUROPEAN JOURNAL OF NEUROLOGY, 2009, 16 (10) : 1090 - 1099
  • [10] RECENT ADVANCES IN THE UNDERSTANDING OF JEMBRANA DISEASE
    WILCOX, GE
    CHADWICK, BJ
    KERTAYADNYA, G
    [J]. VETERINARY MICROBIOLOGY, 1995, 46 (1-3) : 249 - 255
12345