Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation

被引：135
|
作者：
Klein, Stefanie [1 ,2 ]
Sommer, Anja [1 ,2 ]
Distel, Luitpold V. R. [3 ]
Neuhuber, Winfried [4 ]
Kryschi, Carola [1 ,2 ]
机构：
[1] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91058 Erlangen, Germany
[2] Univ Erlangen Nurnberg, ICMM, D-91058 Erlangen, Germany
[3] Univ Erlangen Nurnberg, Dept Radiat Oncol, D-91054 Erlangen, Germany
[4] Univ Erlangen Nurnberg, Dept Anat, Chair Anat 1, D-91054 Erlangen, Germany
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 425卷 / 02期
关键词：
Fenton reaction; Haber-Weiss reaction; Radiosensitizer; Reactive oxygen species; Superparamagnetic iron oxide nanoparticles; MAGNETIC NANOPARTICLES; IN-VIVO; CANCER; CYTOTOXICITY; MECHANISM; TOXICITY; RADICALS; THERAPY; CELLS;
D O I：
10.1016/j.bbrc.2012.07.108
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Internalization of citrate-coated and uncoated superparamagnetic iron oxide nanoparticles by human breast cancer (MCF-7) cells was verified by transmission electron microscopy imaging. Cytotoxicity studies employing metabolic and trypan blue assays manifested their excellent biocompatibility. The production of reactive oxygen species in iron oxide nanoparticle loaded MCF-7 cells was explained to originate from both, the release of iron ions and their catalytically active surfaces. Both initiate the Fenton and Haber-Weiss reaction. Additional oxidative stress caused by X-ray irradiation of MCF-7 cells was attributed to the increase of catalytically active iron oxide nanoparticle surfaces. (c) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：393 / 397
页数：5
相关论文
共 50 条
  • [1] Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation
    Buyukhatipoglu, Kivilcim
    Clyne, Alisa Morss
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2011, 96A (01) : 186 - 195
  • [2] Activatable superparamagnetic iron oxide nanoparticles scavenge reactive oxygen species in macrophages and endothelial cells
    Nwasike, Chukwuazam
    Yoo, Eunsoo
    Purr, Erin
    Doiron, Amber L.
    RSC ADVANCES, 2020, 10 (68) : 41305 - 41314
  • [3] Superparamagnetic iron oxide nanoparticles exacerbate the risks of reactive oxygen species-mediated external stresses
    Cheng Luo
    Yan Li
    Liang Yang
    Xun Wang
    Jiangang Long
    Jiankang Liu
    Archives of Toxicology, 2015, 89 : 357 - 369
  • [4] Superparamagnetic iron oxide nanoparticles exacerbate the risks of reactive oxygen species-mediated external stresses
    Luo, Cheng
    Li, Yan
    Yang, Liang
    Wang, Xun
    Long, Jiangang
    Liu, Jiankang
    ARCHIVES OF TOXICOLOGY, 2015, 89 (03) : 357 - 369
  • [5] Superparamagnetic iron oxide nanoparticles used as contrast agents induce radical oxygen species formation in human macrophages
    Lunov, O.
    Syrovets, T.
    Buechele, B.
    Landfester, K.
    Simmet, T.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2009, 379 : 40 - 41
  • [6] Chitosan Nanococktails Containing Both Ceria and Superparamagnetic Iron Oxide Nanoparticles for Reactive Oxygen Species-Related Theranostics
    Wu, Yuao
    Zhang, Run
    Tran, Huong D. N.
    Kurniawan, Nyoman D.
    Moonshi, Shehzahdi S.
    Whittaker, Andrew K.
    Ta, Hang T.
    ACS APPLIED NANO MATERIALS, 2021, 4 (04) : 3604 - 3618
  • [7] Ultrasmall superparamagnetic iron oxide nanoparticles for enhanced tumor penetration
    Feng, Xue
    Xue, Yuxiang
    Gonca, Sevil
    Ji, Kunlang
    Zhang, Mei
    Garcia-Garcia, Francisco R.
    Li, Quan
    Huang, Yi
    Kamenev, Konstantin V.
    Chen, Xianfeng
    JOURNAL OF MATERIALS CHEMISTRY B, 2023, 11 (15) : 3422 - 3433
  • [8] Effect of Silver Nanoparticles toward DNA via Formation of Reactive Oxygen Species
    Nemcekova, Katarina
    Sochr, Jozef
    Labuda, Jan
    PROCEEDINGS OF INTERNATIONAL CONFERENCE MODERN ELECTROCHEMICAL METHODS XXXIX, 2019, : 163 - 166
  • [9] Iron-dependent formation of reactive oxygen species and glutathione depletion after accumulation of magnetic iron oxide nanoparticles by oligodendroglial cells
    Michaela C. Hohnholt
    Ralf Dringen
    Journal of Nanoparticle Research, 2011, 13 : 6761 - 6774
  • [10] Iron-dependent formation of reactive oxygen species and glutathione depletion after accumulation of magnetic iron oxide nanoparticles by oligodendroglial cells
    Hohnholt, Michaela C.
    Dringen, Ralf
    JOURNAL OF NANOPARTICLE RESEARCH, 2011, 13 (12) : 6761 - 6774
12345