Twists and turns of invasion

被引：6
|
作者：
Childs, Geoffrey [1 ]
Segall, Jeffrey E. [1 ,2 ]
机构：
[1] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA
来源：
NATURE CELL BIOLOGY | 2012年 / 14卷 / 04期
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; GASTRIC-CANCER; BREAST-CANCER; CELL INVASION; TGF-BETA; METASTASIS; ACTIVATION;
D O I：
10.1038/ncb2477
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The transcription factor Twist1 is overexpressed in tumours and can induce the epithelial-mesenchymal transition, resulting in increased invasiveness. Twist1 is now shown to regulate cancer cell migration and invasion in three-dimensional environments by activating the RAC1 GTPase through suppression of a let-7 microRNA family member.
引用
收藏
页码：337 / 339
页数：4
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