Twists and turns of invasion

被引：6

作者：

Childs, Geoffrey ^{[1
]}

Segall, Jeffrey E. ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

来源：

NATURE CELL BIOLOGY | 2012年 / 14卷 / 04期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; GASTRIC-CANCER; BREAST-CANCER; CELL INVASION; TGF-BETA; METASTASIS; ACTIVATION;

D O I：

10.1038/ncb2477

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The transcription factor Twist1 is overexpressed in tumours and can induce the epithelial-mesenchymal transition, resulting in increased invasiveness. Twist1 is now shown to regulate cancer cell migration and invasion in three-dimensional environments by activating the RAC1 GTPase through suppression of a let-7 microRNA family member.

引用

页码：337 / 339

页数：4

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