Synthesis, crystal structure, DNA-binding properties, and antioxidant activity of a V-shaped ligand bis(N-methylbenzimidazol-2-ylmethyl)benzylamine and its zinc(II) complex

被引：16
|
作者：
Wu, Huilu [1 ,2 ]
Yuan, Jingkun [2 ]
Bai, Ying [2 ]
Pan, Guolong [2 ]
Wang, Hua [2 ]
Shao, Juanhui [2 ]
Gao, Jiali [2 ]
Wang, Yaoyu [1 ]
机构：
[1] Northwest Univ, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Coll Chem & Mat Sci, Xian 710069, Peoples R China
[2] Lanzhou Jiaotong Univ, Sch Chem & Biol Engn, Lanzhou 730070, Peoples R China
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2012年 / 65卷 / 24期
关键词：
Benzimidazole; Zinc(II) complex; Crystal structure; DNA-binding property; Antioxidant property; TRANSITION-METAL-COMPLEXES; BENZOYL HYDRAZONE; COPPER(II) COMPLEXES; RUTHENIUM COMPLEXES; HYDROXYL RADICALS; ZN(II) COMPLEXES; HALIDE-COMPLEXES; CU(II) COMPLEX; SCHIFF-BASES; SOLID-STATE;
D O I：
10.1080/00958972.2012.741229
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A V-shaped ligand bis(N-methylbenzimidazol-2-ylmethyl)benzylamine (L) and its zinc(II) complex, [ZnL 2](pic)2?.?2CH3CN (pic?=?picrate), have been synthesized and characterized by physico-chemical and spectroscopic methods. Single-crystal X-ray crystallographic analysis revealed that the Zn(II) complex possesses a distorted trigonal bipyramidal geometry. Supramolecular interactions arising from various intra- or intermolecular p center dot center dot center dot p stacking interactions contributed to the form of the multidimensional configuration. Interactions of L and Zn(II) complex with DNA were monitored using spectrophotometric methods and viscosity measurements. The results suggest that L and Zn(II) complex both bind to DNA via intercalation and Zn(II) complex binds to DNA more strongly than L. Moreover, the Zn(II) complex also exhibited potential antioxidant properties in vitro.
引用
收藏
页码：4327 / 4341
页数：15
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