Pre-XDR & XDR in MDR and Ofloxacin and Kanamycin resistance in non-MDR Mycobacterium tuberculosis isolates

被引：21
|
作者：
Jain, Amita [1 ]
Dixit, Pratima [1 ]
Prasad, Rajendra [2 ]
机构：
[1] CSM Med Univ, Dept Microbiol, Lucknow 226003, Uttar Pradesh, India
[2] CSM Med Univ, Dept Pulm Med, Lucknow 226003, Uttar Pradesh, India
来源：
TUBERCULOSIS | 2012年 / 92卷 / 05期
关键词：
M; tuberculosis; Drug resistance; MDR-TB; XDR-TB; Pre-; 2ND-LINE DRUG-RESISTANCE; MULTIDRUG; SURVEILLANCE; PREVALENCE; PATTERNS; STATE;
D O I：
10.1016/j.tube.2012.05.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Resistance to second line anti tubercular drugs is a cause of serious concern. The present study reports the prevalence of Ofloxacin (OFX) and Kanamycin (KM) resistance in Mycobacterium tuberculosis isolates from cases of pulmonary tuberculosis, who received anti tubercular treatment for >4 weeks in past. Of total 438 enrolled patients, 361 were culture positive for M. tuberculosis, of which, 95 (26.3%) were OFX resistant & 49 (13.5%) were KM resistant. Total 130 isolates were Multidrug resistant, of which, 55 (42.3%) were resistant to either OFX or KM (Pre-XDR) & 11 (8.5%) were resistant to both KM & OFX (XDR). Resistance to quinolones & aminoglycosides should be routinely assessed in areas endemic for tuberculosis. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：404 / 406
页数：3
相关论文
共 50 条
  • [41] PREVALENCE OF MUTATIONS AT CODON 463 OF katG GENE IN MDR AND XDR CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS IN BELARUS AND APPLICATION OF THE METHOD IN RAPID DIAGNOSIS
    Arjomandzadegan, M.
    Owlia, P.
    Ranjbar, R.
    Farazi, A. A.
    Sofian, Masume
    Sadrnia, Maryam
    Ghaznavi-Rad, E.
    Surkova, Larisa K.
    Titov, L. P.
    ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 2011, 58 (01) : 51 - 63
  • [42] Variability of resistance of Mycobacterium tuberculosis based on whole genome sequencing in patients with MDR and XDR-TB in the Kharkiv region,Ukraine
    Butova, T.
    Kuzhko, M.
    Solodiankin, O.
    Rudova, N.
    Tkachenko, A.
    Butov, D.
    Harris, M.
    Gabrielian, A.
    Hurt, D.
    Rosenthal, A.
    EUROPEAN RESPIRATORY JOURNAL, 2022, 60
  • [43] MDR/XDR-TB Colour Test for drug susceptibility testing of Mycobacterium tuberculosis, Northwest Ethiopia
    Shibabaw, Agumas
    Gelaw, Baye
    Kelley, Holden V.
    Tesfaye, Ephrem
    Balada-Llasat, Joan Miquel
    Evans, Carlton A.
    Torrelles, Jordi B.
    Wang, Shu-Hua
    Tessema, Belay
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 90 : 213 - 218
  • [44] Two cases of iatrogenic levofloxacin-resistant pre-XDR tuberculosis in Japan
    Ukai, Tomohiko
    Ohkado, Akihiro
    Okumura, Masao
    Yoshiyama, Takashi
    JOURNAL OF INFECTION AND CHEMOTHERAPY, 2025, 31 (01)
  • [45] Age of Antibiotic Resistance in MDR/XDR Clinical Pathogen of Pseudomonas aeruginosa
    Kothari, Ashish
    Kherdekar, Radhika
    Mago, Vishal
    Uniyal, Madhur
    Mamgain, Garima
    Kalia, Roop Bhushan
    Kumar, Sandeep
    Jain, Neeraj
    Pandey, Atul
    Omar, Balram Ji
    PHARMACEUTICALS, 2023, 16 (09)
  • [46] Methods for Genome-Wide Analysis of MDR and XDR Tuberculosis from Belarus
    Sergeev, Roman
    Kavaliou, Ivan
    Gabrielian, Andrei
    Rosenthal, Alex
    Tuzikov, Alexander
    BIOINFORMATICS RESEARCH AND APPLICATIONS, ISBRA 2016, 2016, 9683 : 258 - 268
  • [47] Linezolid-Associated Neuropathy in Patients with MDR/XDR Tuberculosis in Shenzhen, China
    Zhang, Peize
    Li, Wei
    Liu, Miaona
    Zhan, Senlin
    Zhang, Hailin
    Deng, Guofang
    Chen, Xiaoyou
    INFECTION AND DRUG RESISTANCE, 2022, 15 : 2617 - 2624
  • [48] Resistance to pyrazinamide and ethambutol compromises MDR/XDR-TB treatment
    Hoek, K. G. P.
    Schaaf, H. S.
    Gey van Pittius, N. C.
    van Helden, P. D.
    Warren, R. M.
    SAMJ SOUTH AFRICAN MEDICAL JOURNAL, 2009, 99 (11): : 785 - 787
  • [49] An Insight into MptpB Inhibitors as a Key Strategy to Treat MDR and XDR-Tuberculosis
    Jain, Madhur
    Gollapudi, Sirisha
    Khatik, Gopal L.
    CURRENT PHARMACEUTICAL DESIGN, 2023, 29 (08) : 562 - 575
  • [50] Circulation of Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis Strains in Mexico
    Vazquez-Chacon, Carlos A.
    Martinez-Guarneros, Armando
    Campos, Susana Balandrano
    Herrera, Julieta Luna
    Baecker, Claudia
    Goncalves Rossi, Livia Maria
    Ruiz-Tovar, Karina
    Fonseca-Coronado, Salvador
    Carpio-Pedroza, Juan C.
    Vaughan, Gilberto
    Escobar-Gutierrez, Alejandro
    AMERICAN JOURNAL OF INFECTIOUS DISEASES, 2014, 10 (04) : 174 - 178
12345