First Order Kinetics of Salicylamide Release from κ-Carrageenan Hard Shell Capsules in Comparison with Gelatin

被引：0

作者：

Pudjiastuti, P. ^{[1
]}

Hendradi, E. ^{[2
]}

Wafiroh, S. ^{[1
]}

Darmokoesoemo, H. ^{[1
]}

Fauzi, M. A. R. D. ^{[1
]}

Nahar, L. ^{[3
]}

Sarker, S. D. ^{[3
]}

机构：

[1] Univ Airlangga, Fac Sci & Technol, Dept Chem, Surabaya 60115, Indonesia

[2] Univ Airlangga, Fac Pharm, Dept Pharmaceut, Surabaya 60115, Indonesia

[3] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Med Chem & Nat Prod Res Grp, Byrom St, Liverpool L3 3AF, Merseyside, England

来源：

12TH CONGRESS OF INDONESIAN SOC. FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY IN CONJUNCTION WITH THE 2ND INT. CONF COLLABORATION SEMINAR OF CHEMISTRY AND INDUSTRY (COSCI) AND ANMICRO WORKSHOP, 2018 | 2019年 / 217卷

关键词：

Drug Release Kinetics; Salicylamide; Hard Shell Capsules; Carrageenan;

D O I：

10.1088/1755-1315/217/1/012009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drug delivery material is one of popular topics of research in this era because the developmet of medicines require a good carrier of the drugs produced and synthesized. However, recent produced capsules were made from animal's extract such as bone or skin that could not be suitable for everyone, especially the ones with animal's meat intolerant. Hard shell capsules were produced from kappa-carrageenan-alginate ( CA) and kappa-carrageenan-starch ( CS) of cassava. First order kinetics of salicylamide released from hard shell capsules of CA and CS were determined using the Noyes-Whitney modification equations. The optimum k(1) of gelatin capsules calculated was 0.0108 ppm/min at pH 6.8, CA was 0.0.0493 ppm/min, and CS was 0.0237 ppm/min. This means that CA and CS could be recommended. Further development is needed to produce the best CA and CS capsules as drug delivery material.

引用

页数：5

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