Transition-Metal-Free Sonogashira-Type Cross-Coupling of Alkynes with Fluoroarenes

被引：41
|
作者：
Jin, Guanyi [1 ]
Zhang, Xuxue [1 ]
Cao, Song [1 ,2 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 12期
基金：
中国国家自然科学基金;
关键词：
COPPER-FREE; GRIGNARD-REAGENTS; ARYL CHLORIDES; PALLADIUM; ALKYNYLATION; CATALYSTS; HYDRODEFLUORINATION; TRIFLUOROTOLUENES; POLYFLUOROARENES; ALKYLATION;
D O I：
10.1021/ol401317m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel, inexpensive, and efficient palladium-, copper-, ligand-, and amine-free Sonogashira-type cross-coupling reaction of terminal alkynes with unreactive aryl fluorides in the presence of sodium, sodium methoxide, and calcium hydroxide under the assistance of a Grignard reagent was developed. A plausible mechanism was also suggested.
引用
收藏
页码：3114 / 3117
页数：4
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