Toward the next generation of NK cell-based adoptive cancer immunotherapy

被引：15

作者：

Ni, Jing ^{[1
]}

Miller, Matthias ^{[1
]}

Stojanovic, Ana ^{[1
]}

Cerwenka, Adelheid ^{[1
]}

机构：

[1] German Canc Res Ctr, Jr Res Grp Innate Immun, Heidelberg, Germany

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 04期

关键词：

cancer; CD4(+) T cells; immunotherapy; natural killer cells; radiation therapy; NATURAL-KILLER-CELLS;

D O I：

10.4161/onci.23811

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The adoptive transfer of interleukin (IL)-2-expanded natural killer (NK) cells has provided unsatisfactory clinical benefits to patients affected by solid tumors. Our study demonstrates that the activation of NK cells with IL-12/IL-15/IL-18 prior to transfer into tumor-bearing mice is critical for obtaining high recovery rates, effector functions in vivo and tumor regression.

引用

页数：3

共 50 条

[41] Challenges of NK cell-based immunotherapy in the new era
Fang Fang
Weihua Xiao
Zhigang Tian
Frontiers of Medicine, 2018, 12 : 440 - 450
[42] NK Cell-Based Immunotherapies in Cancer
Shin, Min Hwa
Kim, Junghee
Lim, Siyoung A.
Kim, Jungwon
Kim, Seong-Jin
Lee, Kyung-Mi
IMMUNE NETWORK, 2020, 20 (02)
[43] Adoptive immunotherapy for cancer: the next generation of gene-engineered immune cells
Berry, L. J.
Moeller, M.
Darcy, P. K.
TISSUE ANTIGENS, 2009, 74 (04): : 277 - 289
[44] Cell-based immunotherapy in oesophageal cancer
Lahouty, Masoud
Soleymanzadeh, Amirhossein
Kazemi, Sama
Saadati-Maleki, Haniyeh
Masoudi, Sanaz
Ghasemi, Arash
Kazemi, Tohid
Mehranfar, Sahar
Fadaee, Manouchehr
JOURNAL OF DRUG TARGETING, 2025,
[45] Dendritic cell-based immunotherapy of cancer
Zitvogel, L
Angevin, E
Tursz, T
ANNALS OF ONCOLOGY, 2000, 11 : 199 - 205
[46] B Cell-Based Cancer Immunotherapy
Wennhold, Kerstin
Shimabukuro-Vornhagen, Alexander
von Bergwelt-Baildon, Michael
TRANSFUSION MEDICINE AND HEMOTHERAPY, 2019, 46 (01) : 36 - 46
[47] Dendritic cell-based cancer immunotherapy
Engleman, EG
SEMINARS IN ONCOLOGY, 2003, 30 (03) : 23 - 29
[48] Nanoparticle Enhancement of Natural Killer (NK) Cell-Based Immunotherapy
Murugan, Dhanashree
Murugesan, Vasanth
Panchapakesan, Balaji
Rangasamy, Loganathan
CANCERS, 2022, 14 (21)
[49] Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis
Pan, Rongqing
Ryan, Jeremy
Pan, Deng
Wucherpfennig, Kai W.
Letai, Anthony
CELL, 2022, 185 (09) : 1521 - +
[50] Sweet way to boost the efficacy of NK cell-based immunotherapy
Wu, Peng
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257

← 1 2 3 4 5 →