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Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Dept Cardiol,Vasc Ctr,Guangdong Cardiovasc Inst, 96 Dongchuan Rd, Guangzhou 510080, Guangdong, Peoples R China Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Dept Cardiol,Vasc Ctr,Guangdong Cardiovasc Inst, 96 Dongchuan Rd, Guangzhou 510080, Guangdong, Peoples R China