Whole genomic analysis reveals the co-evolutionary phylodynamics of Korean G9P[8] human rotavirus strains

被引:2
|
作者
Van Thai Than [1 ]
Baek, In Hyuk [1 ]
Kim, Wonyong [1 ]
机构
[1] Chung Ang Univ, Coll Med, Dept Microbiol, Seoul 156756, South Korea
基金
新加坡国家研究基金会;
关键词
G9P[8; Phylogenetic analysis; Rotavirus; NSP3; MOLECULAR CHARACTERIZATION; WA-LIKE; G9; GENOTYPE; PORCINE; DIARRHEA; CHILDREN; EFFICACY; SEQUENCE; VACCINE;
D O I
10.1007/s00705-013-1662-2
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Three human rotavirus G9P[8] strains, RVA/Human-tc/KOR/CAU05-202/2005/G9P[8], RVA/Human-tc/KOR/CAU09-371/2009/G9P[8], and RVA/Human-tc/KOR/CAU09-376/2009/G9P[8], were isolated from female pediatric patients with diarrhea from 2005 to 2009 using a cell culture system, and their complete genomic sequences were analyzed. The 11 gene segments of the three Korean strains possessed the G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1 genotype, which is closely related to the Wa-like genotype 1 constellation. Interestingly, the NSP2 and the NSP3 genes of strain RVA/Human-tc/KOR/CAU09-376/2009/G9P[8] were related to the G9 porcine or human-porcine reassortant strains, providing evidence for porcine-to-human interspecies transmission.
引用
收藏
页码:1795 / 1803
页数:9
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