Hemoglobin and red blood cells as tools for studying peroxynitrite biochemistry

被引：11
|
作者：
Romero, N
Radi, R
机构：
[1] Univ Republica, Fac Med, Dept Bioquim, Montevideo 11800, Uruguay
[2] Univ Republica, Fac Med, Ctr Free Radical & Biomed Res, Montevideo 11800, Uruguay
来源：
NITRIC OXIDE, PT E | 2005年 / 396卷
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0076-6879(05)96021-7
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxyhemoglobin represents a relevant intravascular sink of peroxynitrite. Indeed, peroxynitrite undergoes a fast isomerization (k = 1.7 X 10(4) M(-1)s(-1)) to nitrate in the presence of oxyhemoglobin; the reaction mechanism is complex and leads to methemoglobin and superoxide radical as additional products and a small amount (similar to 10%) of transient species, including ferrylhemoglobin, nitrogen dioxide, and globin-derived radicals.
引用
收藏
页码：229 / 245
页数：17
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