HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS

被引:1
|
作者
Borys-Wojcik, S. [1 ]
Brazert, M. [2 ]
Jankowski, M. [1 ]
Ozegowska, K. [2 ]
Chermula, B. [2 ]
Piotrowska-Kempisty, H. [3 ]
Bukowska, D. [4 ]
Antosik, P. [4 ]
Pawelczyk, L. [2 ]
Nowicki, M. [5 ]
Jeseta, M. [6 ,7 ]
Kempisty, B. [1 ,5 ,6 ,7 ]
机构
[1] Poznan Univ Med Sci, Dept Anat, Poznan, Poland
[2] Poznan Univ Med Sci, Div Infertil & Reprod Endocrinol, Dept Gynecol Obstet & Gynecol Oncol, Poznan, Poland
[3] Poznan Univ Med Sci, Dept Toxicol, Poznan, Poland
[4] Nicolaus Copernicus Univ Torun, Vet Ctr, Torun, Poland
[5] Poznan Univ Med Sci, Dept Histol & Embryol, Poznan, Poland
[6] Univ Hosp, Dept Obstet & Gynecol, Brno, Czech Republic
[7] Masaryk Univ, Brno, Czech Republic
来源
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2019年 / 33卷 / 01期
关键词
mesenchymal stem cells; WJ; properties; isolation; clinical application; HUMAN UMBILICAL-CORD; ADIPOSE-TISSUE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Human Wharton's jelly mesenchymal stem cells (WJ-MSCs) exhibit CD29, CD79 and CD105 markers, characteristic for mesenchymal cell lines. Under the influence of the appropriate factors, WJ-MSCs can be dedifferentiated to osteoblasts, chondrocytes, adipocytes, myocytes, cardiomyocytes, glial cells and dopaminergic neurons. Wharton's jelly (WJ) is one of the potential sources of mesenchymal stem cells (MSCs) - obtaining these cells does not raise moral or ethical objections, because the umbilical cord (UC) is a regular waste material. The expression of the OCT-4 and Nanog proteins, which are characteristic for WJ-MSCs may indicate that these cells have retained some embryonic character. The collected data suggests that WJMSCs show increased division and telomerase activity compared to bone marrow MSCs (BM-MSCs). The published results showed no human leucocyte antigen (HLA) class II expression, with the possibility of HLA class I modification by WJ-MSCs, allowing for the transplantation of these cells both within the same and other species - which allows the use of human cells in animal models. The results of selected studies indicate that WJ-MSCs can be an essential element of regenerative medicine of the 21st century.
引用
收藏
页码:119 / 123
页数:5
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