Synthesis of azetidin-2-one derivatives as inhibitor of secretory phospholipase A2 with anti-inflammatory activity

被引：0
|
作者：
Yerigeri, MC [1 ]
Murari, SK
Mohammed, S
Math, SKS
Thimmaiah, KN
Vishwanath, BS
机构：
[1] VL Coll Pharm, Dept Med Chem, Raichur 584103, India
[2] Western Illinois Univ, Dept Chem, Macomb, IL 61455 USA
[3] Univ Mysore, Dept Studies Biochem, Mysore 570006, Karnataka, India
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2005年 / 2卷 / 04期
关键词：
phospholipase A(2) (PLA(2)); anti-inflammatory; azetidin-2-one derivatives;
D O I：
10.2174/1570180054038404
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The title compounds have been synthesized and tested for structure activity relationship for Phospholipase A(2) (PLA(2)) [E.C. 3.1.1.4] enzyme inhibition. The in vitro PLA(2) enzyme inhibitory activity of azetidin-2-one derivatives and in vivo anti-inflammatory activity studies using mice are highlighted. The results show that some azetidin-2-one derivatives are very good PLA(2) inhibitors and can also be used as anti-inflammatory drugs.
引用
收藏
页码：307 / 310
页数：4
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