Efficient method for thioacetalization of carbonyl compounds in the presence of a catalytic amount of benzyltriphenylphosphonium tribromide (BTPTB) under solvent-free conditions

被引：8

作者：

Hajipour, Abdol Reza ^{[1
]}

Pourmousavi, Seied A. ^{[1
]}

Ruoho, Arnold E. ^{[2
]}

机构：

[1] Isfahan Univ Technol, Dept Chem, Pharmaceut Res Lab, Esfahan 84156, Iran

[2] Univ Wisconsin Med Sci, Dept Pharmacol, Madison, WI USA

来源：

SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 15期

基金：

美国国家卫生研究院;

关键词：

carbonyl compounds; solvent-free; thioacetalization;

D O I：

10.1080/00397910802219197

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of carbonyl compounds have been successfully converted to the corresponding thioacetal derivatives in good to excellent yields on reaction of carbonyl compounds with 1,2-ethanedithiole, 1,3-propanedithiol, and ethylthiol in the presence of a catalytic amount of benzyltriphenylphosphonium tribromide (BTPTB) under solvent-free conditions. Some of the major advantages of this method are mild reaction conditions, high efficiency, and the compatibility with other reported methods. In addition, no bromination occurs at the double bond or to the keto position or even in the aromatic ring under these experimental conditions.

引用

页码：2548 / 2566

页数：19

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