Of sex and determination: marking 25 years of Randy, the sex-reversed mouse

被引：12
|
作者：
Koopman, Peter [1 ]
Sinclair, Andrew [2 ,3 ]
Lovell-Badge, Robin [4 ]
机构：
[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
[2] Univ Melbourne, Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic 3052, Australia
[3] Univ Melbourne, Royal Childrens Hosp, Dept Paediat, Melbourne, Vic 3052, Australia
[4] Francis Crick Inst, Mill Hill, London NW7 1AA, England
来源：
DEVELOPMENT | 2016年 / 143卷 / 10期
基金：
英国医学研究理事会;
关键词：
Sry; Sex determination; Transgenic mouse; Testis; TESTIS-DETERMINING GENE; DNA-BINDING MOTIF; TRANSCRIPTION FACTOR; DETERMINING REGION; Y-CHROMOSOME; TRANSGENIC MICE; SERTOLI-CELLS; SRY; DIFFERENTIATION; EXPRESSION;
D O I：
10.1242/dev.137372
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV were abuzz with the story of a transgenic mouse in London called Randy. Why was this mouse so special? The mouse in question was a chromosomal female (XX) made male by the presence of a transgene containing the Y chromosome gene Sry. This sex-reversal provided clear experimental proof that Sry was the elusive mammalian sex-determining gene. Twenty-five years on, we reflect on what this discovery meant for our understanding of how males and females arise and what remains to be understood.
引用
收藏
页码：1633 / 1637
页数：5
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