Roles of CD4+T cells as mediators of antitumor immunity

被引：29
|
作者：
Kravtsov, Dmitriy S. S. [1 ]
Erbe, Amy K. K. [1 ]
Sondel, Paul M. M. [1 ,2 ]
Rakhmilevich, Alexander L. L. [1 ]
机构：
[1] Univ Wisconsin, Dept Human Oncol, Madison, WI 53792 USA
[2] Univ Wisconsin, Dept Pediat, Madison, WI USA
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金：
美国国家卫生研究院;
关键词：
CD4+T cells; adoptive cell therapy; MHC; cytotoxicity; immunotherapy; CD4(+) T-CELLS; IFN-GAMMA; IN-VIVO; INTERFERON-GAMMA; TUMOR REJECTION; VESSEL NORMALIZATION; CANCER; MEMORY; ANGIOGENESIS; EFFECTOR;
D O I：
10.3389/fimmu.2022.972021
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
It has been well established that CD8+ T cells serve as effector cells of the adaptive immune response against tumors, whereas CD4+ T cells either help or suppress the generation of CD8+ cytotoxic T cells. However, in several experimental models as well as in cancer patients, it has been shown that CD4+ T cells can also mediate antitumor immunity either directly by killing tumor cells or indirectly by activating innate immune cells or by reducing tumor angiogenesis. In this review, we discuss the growing evidence of this underappreciated role of CD4+ T cells as mediators of antitumor immunity.
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页数：9
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