Quality control and clinical application of two bone imaging 99mTc radiopharmaceuticals

被引:4
|
作者
Ayranov, M [1 ]
Strezov, A
Jordanova, A
Piperkova, E
Sergieva, S
机构
[1] Bulgarian Acad Sci, Inst Nucl Res & Nucl Energy, Sofia, Bulgaria
[2] Natl Oncol Ctr, BU-1157 Sofia, Bulgaria
关键词
Chromatography; Nuclear Medicine; Clinical Application; Complex Formation; Thin Layer Chromatography;
D O I
10.1007/BF02349177
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The radiochemical purity of MDP and HEDP has been determined by means of gel chromatography on Sephadex and thin layer chromatography on plastic foil silica gel. The comparison of the two radiopharmaceuticals shows equal level of complex formation with Tc-99m. The biodistribution demonstrated that the application of HEDP allows earlier scanning than MDP. MDP and HEDP show equal effectivity during the clinical investigations. There is no significant difference in the radiochemical purity within six hours after the reconstitution of the freeze-dried kits. HEDP kit demonstrates shorter period of accumulation and equivalent complex formation levels, so it can be used in routine nuclear medicine diagnostics together with MDP kit.
引用
收藏
页码:349 / 352
页数:4
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