Hematopoietic Cell Transplantation for B-Cell Lymphoma: An Update

被引：6
|
作者：
Ayala, Ernesto [1 ]
机构：
[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Blood & Marrow Transplant Program, Tampa, FL 33612 USA
来源：
CANCER CONTROL | 2012年 / 19卷 / 03期
关键词：
HIGH-DOSE THERAPY; PROGRESSION-FREE SURVIVAL; HUMAN-IMMUNODEFICIENCY-VIRUS; Y-90 IBRITUMOMAB TIUXETAN; NON-HODGKINS-LYMPHOMA; INTERNATIONAL PROGNOSTIC INDEX; BONE-MARROW-TRANSPLANTATION; CHEMOTHERAPY PLUS RITUXIMAB; DETUDE-DES-LYMPHOMES; FOLLICULAR LYMPHOMA;
D O I：
10.1177/107327481201900302
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: B-cell lymphoma comprises the majority of non-Hodgkin lymphomas worldwide. Hematopoietic cell transplantation (HCT) is used for patients with high-risk, relapsed, or refractory B-cell lymphoma. Methods: The current medical literature and the results of recently published trials were reviewed to provide an update on the most common indications for HCT in B-cell lymphoma. Results: Autologous HCT has evolving and new roles in the treatment of patients with high-risk diffuse large B-cell cell lymphoma, mantle cell lymphoma, and HIV-related lymphoma. Reduced-intensity conditioning has largely replaced older myeloablative conditioning regimens, making allogeneic transplantation safer for more patients with lymphoma. Conclusions: The indication and timing of HCT depend on the patient's histology, age, and response to previous therapies. HCT is an essential component in the armamentarium to treat B-cell lymphoma.
引用
收藏
页码：175 / 186
页数：12
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