This review summarizes the recent data on the energy metabolism of acetogenic bacteria isolated from saline and soda lakes. It provides a general description of saline and soda lakes as microbial habitats, pert, forms a comparative analysis of the energy metabolism of neutrophilic acetogens, considers the adaptation strategics of halophilic and alkaliphilic acetogens to high salinity and high pH values, while also discussing the mechanisms of energy accumulation under auto- and organotrophic conditions.