Clinical significance of breast ultrasound and FOXP3 in breast cancer patients

To examine clinical significance of breast ultrasound together with forkhead box P3 (Foxp3) detection to istic (ROC) curve was used to assess the diagnostic value of Breast Imaging Reporting and Data System (BI-RADS) classification, Foxp3 mRNA expression and the combination of these two parameters. The value of Foxp3 mRNA expression in the peripheral blood for breast cancer patients was higher than patients with benign breast tumors significantly (P<0.001). The diagnostic sensitivity and specificity of BI-RADS classification, Foxp3 mRNA expression, and the combination of these two were 0.792 and 0.732, 0.875 and 0.625, 0.896 and 0.768, with the area under the curve (AUC) of 0.827 (P<0.001), 0.836 (P<0.001) and 0.910 (P<0.001), respectively. Therefore, this study demonstrated that breast ultrasound BI-RADS classification combined with Foxp3 detection is of higher diagnostic value than that of both, which probably be an effective approach to diagnose breast cancer.