Clinical significance of breast ultrasound and FOXP3 in breast cancer patients

被引:0
|
作者
Lin, Shibin [1 ]
Wan, Ying [1 ]
Huang, Li [1 ]
Chen, Kailiang [1 ]
机构
[1] Hainan Med Univ, Affiliated Hosp 1, Dept Ultrasound, Haikou 570102, Hainan, Peoples R China
关键词
Breast cancer; breast ultrasound; BI-RADS; Foxp3; diagnosis; REGULATORY T-CELLS; EXPRESSION; SIGNATURES; REPRESSOR; DIAGNOSIS; CTLA-4;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
To examine clinical significance of breast ultrasound together with forkhead box P3 (Foxp3) detection to istic (ROC) curve was used to assess the diagnostic value of Breast Imaging Reporting and Data System (BI-RADS) classification, Foxp3 mRNA expression and the combination of these two parameters. The value of Foxp3 mRNA expression in the peripheral blood for breast cancer patients was higher than patients with benign breast tumors significantly (P<0.001). The diagnostic sensitivity and specificity of BI-RADS classification, Foxp3 mRNA expression, and the combination of these two were 0.792 and 0.732, 0.875 and 0.625, 0.896 and 0.768, with the area under the curve (AUC) of 0.827 (P<0.001), 0.836 (P<0.001) and 0.910 (P<0.001), respectively. Therefore, this study demonstrated that breast ultrasound BI-RADS classification combined with Foxp3 detection is of higher diagnostic value than that of both, which probably be an effective approach to diagnose breast cancer.
引用
收藏
页码:4943 / 4948
页数:6
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