A General and Facile Synthesis of Novel Polysubstituted Quinazolin-4(3H)-ones

被引：0
|
作者：
Xin, Minhang [1 ]
Gao, Ying [1 ]
Xiang, Hua [1 ]
Chen, Dong [1 ]
He, Yi [1 ]
You, Qidong [1 ,2 ]
机构：
[1] China Pharmaceut Univ, Dept Med Chem, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Jiangsu Key Lab Carcinogenesis & Intervent, Nanjing 210009, Jiangsu, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 50卷 / 01期
关键词：
ONE-POT SYNTHESIS; SOLVENT-FREE CONDITIONS; RECEPTOR INVERSE AGONISTS; VALENT TITANIUM REAGENT; QUINAZOLINONE DERIVATIVES; ANTHRANILIC ACID; ORTHO ESTERS; 4(3H)-QUINAZOLINONES; EFFICIENT; ANTAGONISTS;
D O I：
10.1002/jhet.1001
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient approach to synthesize novel polysubstituted quinazolin-4(3H)-ones has been developed, and the key step is a sequential procedure involved iron-mediated reduction and acid-catalytic cyclization. The present method provides a convenient and practical strategy for the synthesis of quinazolin-4(3H)-one derivatives.
引用
收藏
页码：169 / 174
页数：6
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