Fetuin-A levels in hyperthyroidism

被引:9
|
作者
Pamuk, Baris Onder [1 ]
Yilmaz, Hamiyet [1 ]
Topcuoglu, Tugba [2 ]
Bilgir, Oktay [2 ]
Calan, Ozlem [3 ]
Pamuk, Gulseren [4 ]
Ertugrul, Derun Taner [5 ]
机构
[1] Izmir Bozyaka Teaching & Res Hosp, Dept Endocrinol & Metab, Izmir, Turkey
[2] Izmir Bozyaka Teaching & Res Hosp, Dept Internal Med, Izmir, Turkey
[3] Izmir Bozyaka Teaching & Res Hosp, Dept Biochem, Izmir, Turkey
[4] Izmir Bozyaka Teaching & Res Hosp, Dept Family Med, Izmir, Turkey
[5] Kecioren Teaching & Res Hosp, Dept Endocrinol & Metab, Ankara, Turkey
关键词
Fetuin-A; Hyperthyroidism; Insulin Resistance; ALPHA(2)-HEREMANS-SCHMID GLYCOPROTEIN/FETUIN-A; INCIDENT DIABETES-MELLITUS; THYROID-HORMONE EXCESS; INSULIN-RESISTANCE; TYROSINE KINASE; SERUM; CALCIFICATION; ASSOCIATION; INHIBITOR; METABOLISM;
D O I
10.6061/clinics/2013(03)OA15
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE:Fetuin-A is a protein secreted from the liver that inhibits arterial calcification deposition and can contribute to insulin resistance. Hyperthyroidism is also associated with insulin resistance. It is not known whether hyperthyroidism has an effect on fetuin-A levels. METHODS:We measured fetuin-A levels and homeostasis model of assessment-insulin resistance before hyperthyroidism treatment was initiated and after euthyroidism was achieved. A total of 42 patients diagnosed with hyperthyroidism were enrolled in this study. Fetuin-A, insulin, high-sensitivity C-reactive protein, fasting blood glucose, free T3 (fT3), free T4 (fT4), and thyrotropin were measured before and after euthyroidism was established. RESULTS:Basal fasting blood glucose, high-sensitivity C-reactive protein, insulin, c-peptide, homeostasis model of assessment-insulin resistance, fT3, fT4 and fetuin-A levels were significantly decreased after euthyroidism was achieved (Table 1). Basal fasting blood glucose (r:0.407, p:0.008), high-sensitivity C-reactive protein (r:0.523, p<0.0001), insulin (r:0.479, p:0.001), homeostasis model of assessment-insulin resistance (r:0.541, p<0.0001), fT3 (r:0.492, p:0.001) and fT4 (r:0.473, p:0.002) were positively correlated with basal fetuin-A levels. Basal thyrotropin levels were significantly negatively correlated (r:-0.553, p<0.0001) with basal fetuin-A levels. CONCLUSION:Our findings suggest that hyperthyroidism influences fetuin-A levels.
引用
收藏
页码:379 / 383
页数:5
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