Cost of prostate image-guided radiation therapy: Results of a randomized trial

被引：38
|
作者：
Perrier, Lionel [1 ]
Morelle, Magali [1 ]
Pommier, Pascal [1 ]
Lagrange, Jean-Leon [2 ]
Laplanche, Agnes [3 ]
Dudouet, Philippe [4 ]
Supiot, Stephane [5 ]
Chauvet, Bruno [6 ]
Tan-Dat Nguyen [7 ]
Crehange, Gilles [8 ]
Beckendorf, Veronique [9 ]
Pene, Francoise [10 ]
Muracciole, Xavier [11 ]
Bachaud, Jean-Marc [12 ]
Le Prise, Elisabeth [13 ]
de Crevoisier, Renaud [13 ,14 ,15 ]
机构：
[1] Leon Berard Canc Ctr, Lyon, France
[2] APHP Univ, Henry Mondor Hosp, Dept Canc & Environm, Creteil, France
[3] Inst Gustave Roussy, Dept Biostat, Villejuif, France
[4] du Pont de Chaume Clin, Dept Radiotherapy, Montauban, France
[5] Rene Gauducheau Canc Ctr, Dept Radiotherapy, St Herblain, France
[6] St Catherine Inst, Dept Biostat, Avignon, France
[7] Jean Godinot Inst, Dept Radiotherapy, Reims, France
[8] Georges Francois Leclerc Ctr, Dept Radiotherapy, Dijon, France
[9] Ctr Alexis Vautrin, Dept Radiotherapy, Vandoeuvre Les Nancy, France
[10] Tenon Hosp, Dept Radiotherapy, Paris, France
[11] de la Timone Hosp, Dept Radiotherapy, Marseille, France
[12] Claudius Regaud Inst, Dept Radiotherapy, Toulouse, France
[13] Eugene Marquis Canc Ctr, F-35042 Rennes, France
[14] INSERM, U1099, Rennes, France
[15] Rennes Univ, Rennes, France
来源：
RADIOTHERAPY AND ONCOLOGY | 2013年 / 106卷 / 01期
关键词：
Image-guided radiotherapy; Prostate; Cost analysis; ADAPTIVE RADIOTHERAPY; BLADDER-CANCER; INCREASED RISK; FAILURE; MARGINS; RECTUM;
D O I：
10.1016/j.radonc.2012.11.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: This cost analysis aimed to quantify the cost of IGRT in relation to IGRT frequency and modality with Cone Beam Computed Tomography (CBCT) or orthogonal electronic portal imaging with fiducial markers (EPI-FM). Material and methods: Patients undergoing IGRT for localized prostate cancer were randomized into two prostate control frequencies (daily or weekly). Costs were calculated based on the micro-costing results according to hospitals' perspectives (in Euros, 2009) and the time horizon was radiation therapy. Results: A total of 208 patients were enrolled in seven French cancer centers. A total of 6865 fractions were individually analyzed. The mean total treatment fraction duration was 21.0 min for daily CBCT and 18.3 min for daily EPI-FM. Increasing the control frequency from weekly to daily increased the mean treatment fraction duration by 7.3 min (+53%) for CBCT and 1.7 min (+10%) for EPI-FM (p <= 0.01). The mean additional cost per patient of daily controls compared with weekly controls was E679 and 187 for CBCT and EPI-FM, respectively (p < 0.0001). Conclusions: The incremental costs due to different prostate IGRT strategies are relatively moderate, suggesting that daily IGRT combined with intensity-modulated RT (IMRT) could be administered in cases of high-dose radiation delivery to the prostate. (C) 2013 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 106 (2013) 50-58
引用
收藏
页码：50 / 58
页数：9
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