Ti(Oi-Pr)4-Promoted Regio- and Stereoselective Aminolysis of 2,3-Epoxy Amides

被引：2

作者：

Righi, Giuliana ^{[1
]}

Mantineo, Agnese

Suber, Lorenza ^{[2
]}

Mari, Alessandra

机构：

[1] Univ Roma La Sapienza, CNR Ist Chim Biomol, Dip Chim, I-00185 Rome, Italy

[2] CNR Ist Struttura Mat, I-00015 Rome, Italy

来源：

SYNLETT | 2012年 / 13期

关键词：

amides; diastereoselectivity; epoxides; regioselectivity; ring opening; ALPHA; BETA-AZIRIDINE ALDEHYDES; NUCLEOPHILIC OPENINGS; ASYMMETRIC-SYNTHESIS; 1,2-AMINO ALCOHOLS; ANALOGS; EPOXIDES; 1,2-EPOXIDES; DERIVATIVES; AMINES; AGENTS;

D O I：

10.1055/s-0032-1316705

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and inexpensive Ti(Oi-Pr)(4)-mediated aminolysis of 2,3-epoxy amides has been developed. The reaction proceeds with excellent regioselectivity, regardless of the steric hindrance of the substituents on the heterocyclic ring, providing vicinal amino alcohols that are very suitable for synthetic applications.

引用

页码：1947 / 1949

页数：3

共 33 条

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