Synthesis of hemslecin A derivatives: A new class of hepatitis B virus inhibitors

被引：17
|
作者：
Guo, Rui-Hua [1 ]
Geng, Chang-An [1 ]
Huang, Xiao-Yan [1 ]
Ma, Yun-Bao [1 ]
Zhang, Quan [1 ]
Wang, Li-Jun [1 ]
Zhang, Xue-Mei [1 ]
Zhang, Rong-Ping [2 ]
Chen, Ji-Jun [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
[2] Kunming Med Univ, Kunming 650500, Yunnan, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Hemslecin A; Derivatives; Hepatitis B virus; SCHISANDRA-WILSONIANA; FRUITS; ALISOL;
D O I：
10.1016/j.bmcl.2013.01.024
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of hemslecin A derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities, namely, inhibiting the secretion of hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and HBV DNA replication on HepG 2.2.15 cells. Most of the derivatives showed enhanced anti-HBV activities, of which compounds A1-A7, B5, C and E exhibited significant activities inhibiting HBV DNA replication with IC50 values of 2.8-11.6 mu M, comparable to that of the positive control, tenofovir. Compounds A1-A3, A5, B5, and C displayed low cytotoxicities, which resulted in high SI values of 89.7, 55.6, 77.8, >83.4, >55.8, and >150.5, respectively. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：1201 / 1205
页数：5
相关论文
共 50 条
  • [41] Advancing hepatitis B virus entry inhibitors
    Verrier, Eloi R.
    Schuster, Catherine
    Baumert, Thomas F.
    JOURNAL OF HEPATOLOGY, 2017, 66 (04) : 677 - 679
  • [42] Design and evaluation of hepatitis B virus inhibitors
    Hantz, O
    Kraus, JL
    Zoulim, F
    CURRENT PHARMACEUTICAL DESIGN, 2000, 6 (05) : 503 - 523
  • [43] RETRACTION: Thiophen urea derivatives as a new class of hepatitis C virus entry inhibitors (Retraction of Vol 36, Pg 462, 2021)
    Ryu, Hyung Chul
    Windisch, Marc
    Lim, Jee Woong
    Choi, Inhee
    Lee, Eun Kyu
    Yoo, Hye Hyun
    Kim, Tae Kon
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 1048 - 1048
  • [44] Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors
    Jadoon, Muhammad Siraj Khan
    Pelletier, Julie
    Sevigny, Jean
    Iqbal, Jamshed
    RSC ADVANCES, 2023, 13 (42) : 29496 - 29511
  • [45] Efficacy of hepatitis B virus ribonuclease H inhibitors, a new class of replication antagonists, in FRG human liver chimeric mice
    Long, Kelly R.
    Lomonosova, Elena
    Li, Qilan
    Ponzar, Nathan L.
    Villa, Juan A.
    Touchette, Erin
    Rapp, Stephen
    Liley, R. Matt
    Murelli, Ryan P.
    Grigoryan, Alexandre
    Buller, R. Mark
    Wilson, Lisa
    Bial, John
    Sagartz, John E.
    Tavis, John E.
    ANTIVIRAL RESEARCH, 2018, 149 : 41 - 47
  • [46] Synthesis and testing of azaglutamine derivatives as inhibitors of hepatitis A virus (HAV) 3C proteinase
    Huang, YT
    Malcolm, BA
    Vederas, JC
    BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (04) : 607 - 619
  • [47] Thiadiazole derivatives as New Class of β-glucuronidase inhibitors
    Salar, Uzma
    Taha, Muhammad
    Ismail, Nor Hadiani
    Khan, Khalid Mohammed
    Imran, Syahrul
    Perveen, Shahnaz
    Wadood, Abdul
    Riaz, Muhammad
    BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (08) : 1909 - 1918
  • [48] Design, Synthesis and Biological Evaluation of Caudatin Analogs as Potent Hepatitis B Virus Inhibitors
    Wang, Li-Jun
    Chen, Hao
    Ma, Yun-Bao
    Huang, Xiao-Yan
    Geng, Chang-An
    Zhang, Xue-Mei
    Chen, Ji-Jun
    MEDICINAL CHEMISTRY, 2015, 11 (02) : 165 - 179
  • [49] Design, Synthesis, and Biological Evaluation of Triazolo-pyrimidine Derivatives as Novel Inhibitors of Hepatitis B Virus Surface Antigen (HBsAg) Secretion
    Yu, Wenquan
    Goddard, Gaily
    Clearfield, Elizabeth
    Mills, Courtney
    Xiao, Tong
    Guo, Haitao
    Morrey, John D.
    Motter, Neil E.
    Zhao, Kang
    Bock, Timothy M.
    Cuconati, Andrea
    Xu, Xiaodong
    JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (16) : 5660 - 5670
  • [50] Synthesis and anti-hepatitis B virus activities of Matijing-Su derivatives
    Xu, Bixue
    Huang, Zhengming
    Liu, Changxiao
    Cai, Zegui
    Pan, Weidong
    Cao, Peixue
    Hao, Xiaojiang
    Liang, Guangyi
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (08) : 3118 - 3125
12345