The Prognostic Significance of Histone Demethylase UTX in Esophageal Squamous Cell Carcinoma

被引:15
|
作者
Li, Shau-Hsuan [1 ,2 ]
Lu, Hung-I [2 ,3 ]
Huang, Wan-Ting [2 ,4 ]
Tien, Wan-Yu [1 ,2 ]
Lan, Ya-Chun [1 ,2 ]
Lin, Wei-Che [2 ,5 ]
Tsai, Hsin-Ting [6 ,7 ]
Chen, Chang-Han [6 ,7 ,8 ,9 ,10 ]
机构
[1] Kaohsiung Chang Gung Mem Hosp, Dept Hematol Oncol, Kaohsiung 833, Taiwan
[2] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan
[3] Kaohsiung Chang Gung Mem Hosp, Dept Thorac & Cardiovasc Surg, Kaohsiung 833, Taiwan
[4] Kaohsiung Chang Gung Mem Hosp, Dept Pathol, Kaohsiung 833, Taiwan
[5] Kaohsiung Chang Gung Mem Hosp, Dept Diagnost Radiol, Kaohsiung 833, Taiwan
[6] Sun Yat Sen Univ, Guangdong Inst Gastroenterol, Guangzhou 510020, Guangdong, Peoples R China
[7] Sun Yat Sen Univ, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Guangzhou 510020, Guangdong, Peoples R China
[8] Natl Chi Nan Univ, Dept Appl Chem, Nantou 54561, Taiwan
[9] Natl Chi Nan Univ, Grad Inst Biomed & Biomed Technol, Nantou 54561, Taiwan
[10] Kaohsiung Med Univ, Ctr Infect Dis & Canc Res, Kaohsiung 807, Taiwan
关键词
esophageal cancer; squamous cell carcinoma; UTX; E-cadherin; E-CADHERIN EXPRESSION; KABUKI SYNDROME; CANCER CELLS; INHIBITION; MUTATIONS; PATHWAY; DISEASE; KDM6A;
D O I
10.3390/ijms19010297
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The dysregulation of the ubiquitously transcribed TPR gene on the X chromosome (UTX) has been reported to be involved in the oncogenesis of several types of cancers. However, the expression and significance of UTX in esophageal squamous cell carcinoma (ESCC) remains largely undetermined. Immunohistochemistry was performed in 106 ESCC patients, and correlated with clinicopathological features and survival. The functional role of UTX in ESCC cells was determined by UTX-mediated siRNA. Univariate analyses showed that high UTX expression was associated with superior overall survival (OS, p = 0.011) and disease-free survival (DFS, p = 0.01). UTX overexpression was an independent prognosticator in multivariate analysis for OS (p = 0.013, hazard ratio = 1.996) and DFS (p = 0.009, hazard ratio = 1.972). The 5-year OS rates were 39% and 61% in patients with low expression and high expression of UTX, respectively. Inhibition of endogenous UTX in ESCC cells increased cell viability and BrdU incorporation, and decreased the expression of epithelial marker E-cadherin. Immunohistochemically, UTX expression was also positively correlated with E-cadherin expression. High UTX expression is independently associated with a better prognosis in patients with ESCC and downregulation of UTX increases ESCC cell growth and decreases E-cadherin expression. Our results suggest that UTX may be a novel therapeutic target for patients with ESCC.
引用
收藏
页数:11
相关论文
共 50 条
  • [31] The prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma
    Bowen Liu
    Bo Cheng
    Cong Wang
    Pengxiang Chen
    Yufeng Cheng
    Scientific Reports, 8
  • [32] Prognostic significance of interferon regulating factor 4 in esophageal squamous cell carcinoma
    Sun, Ran
    Ye, Lin
    Zhang, Min
    Qiu, Zhu
    Xiang, Tingxiu
    Tang, Jun
    Wang, Xiangyu
    Li, Lili
    Luo, Jie
    Zhang, Dongsheng
    Ren, Guosheng
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 506 (03) : 685 - 691
  • [33] Prognostic significance of CDK6 amplification in esophageal squamous cell carcinoma
    Liu, Kun
    Lu, Huadong
    Jiang, Dongxian
    Guan, Yingying
    Xu, Huijuan
    Sun, Qi
    Jiang, Qiuli
    Zheng, Jingmei
    Chen, Huan
    Zhang, Fuhan
    Luo, Ruichen
    Huang, Ying
    Xu, Jianfang
    Hou, Yingyong
    CANCER TREATMENT AND RESEARCH COMMUNICATIONS, 2023, 35
  • [34] Phenotypic profiling and prognostic significance of immune infiltrates in esophageal squamous cell carcinoma
    Pan, Chuqing
    Wang, Yu
    Liu, Qianwen
    Hu, Yihuai
    Fu, Jianhua
    Xie, Xiuying
    Zhang, Shuishen
    Xi, Mian
    Wen, Jing
    ONCOIMMUNOLOGY, 2021, 10 (01):
  • [35] The prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma
    Liu, Bowen
    Cheng, Bo
    Wang, Cong
    Chen, Pengxiang
    Cheng, Yufeng
    SCIENTIFIC REPORTS, 2018, 8
  • [36] Coexpression of periostin and EGFR in patients with esophageal squamous cell carcinoma and their prognostic significance
    Jia, Wei
    Wang, Wei
    Ji, Chu-shu
    Niu, Jun-yang
    Lv, Ya-jing
    Zhou, Hang-cheng
    Hu, Bing
    ONCOTARGETS AND THERAPY, 2016, 9 : 5133 - 5142
  • [37] Prognostic significance of neutrophil-to-lymphocyte ratio in esophageal squamous cell carcinoma
    Sakin, Aysegul
    Alay, Murat
    Sahin, Suleyman
    Aydemir, Ozan
    Aldemir, Mehmet Naci
    Sakin, Abdullah
    Kotan, Cetin
    NORTHERN CLINICS OF ISTANBUL, 2021, 8 (05) : 435 - 442
  • [38] Clinical Significance of Prognostic Nutritional Index in the Treatment of Esophageal Squamous Cell Carcinoma
    Takao, Koji
    Konishi, Hirotaka
    Fujiwara, Hitoshi
    Shiozaki, Atsushi
    Shoda, Katsutoshi
    Kosuga, Toshiyuki
    Kubota, Takeshi
    Arita, Tomohiro
    Morimura, Ryo
    Murayama, Yasutoshi
    Kuriu, Yoshiaki
    Ikoma, Hisashi
    Nakanishi, Masayoshi
    Okamoto, Kazuma
    Otsuji, Eigo
    IN VIVO, 2020, 34 (06): : 3451 - 3457
  • [39] Prognostic significance of serum thymidine phosphorylase concentration in esophageal squamous cell carcinoma
    Shimada, H
    Takeda, A
    Shiratori, T
    Nabeya, Y
    Okazumi, S
    Matsubara, H
    Funami, Y
    Hayashi, H
    Gunji, Y
    Kobayashi, S
    Suzuki, T
    Ochiai, T
    CANCER, 2002, 94 (07) : 1947 - 1954
  • [40] Function and prognostic significance of sodium iodide symporter in esophageal squamous cell carcinoma
    Ariyoshi, Yosuke
    Shiozaki, Atsushi
    Ichikawa, Daisuke
    Iitaka, Daisuke
    Kosuga, Toshiyuki
    Konishi, Hirotaka
    Kubota, Kubota
    Fujiwara, Hitoshi
    Okamoto, Okamoto
    Kishimoto, Mitsuo
    Marunaka, Yoshinori
    Otsuji, Eigo
    CANCER SCIENCE, 2018, 109 : 695 - 695