Synthesis and biological evaluation of novel selenonucleosides

被引：2
|
作者：
Chen, Yao [2 ]
Peng, Yingdan [2 ]
Zhang, Jiancun [1 ]
Fu, Lei [2 ]
机构：
[1] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2008年 / 27卷 / 08期
关键词：
synthesis; biological evaluation; selenonucleoside; 1,4-oxaselenane;
D O I：
10.1080/15257770802088803
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleoside analogues were evaluated as potential antitumor agents.
引用
收藏
页码：1001 / 1008
页数：8
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