Bcl-2 family members: Essential players in skin cancer

被引：27
|
作者：
Nys, Kris [1 ]
Agostinis, Patrizia [1 ]
机构：
[1] Catholic Univ Louvain, Dept Mol Cell Biol, Cell Death Res & Therapy Unit, B-3000 Louvain, Belgium
来源：
CANCER LETTERS | 2012年 / 320卷 / 01期
关键词：
Skin; UVB; Skin cancer; Bcl-2; family; Apoptosis; SQUAMOUS-CELL CARCINOMA; UVB-INDUCED APOPTOSIS; HUMAN-MELANOMA CELLS; NERVE GROWTH-FACTOR; RADIATION-INDUCED APOPTOSIS; ULTRAVIOLET-B RADIATION; HUMAN MELANOCYTES; HUMAN KERATINOCYTES; UP-REGULATION; EPIDERMAL-KERATINOCYTES;
D O I：
10.1016/j.canlet.2012.01.031
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Skin cancer has reached epidemic proportions and is considered to be a direct consequence of ultraviolet (UV) radiation exposure. Excessive exposure of epidermal cells to UV results in apoptosis of irreparably damaged cells to avoid malignant transformation. The Bcl-2 family of proteins is emerging as a crucial regulator of epidermal homeostasis and cell's fate in the stressed skin. Not surprisingly, deregulation of Bcl-2 family members is also chiefly involved in skin carcinogenesis and response to cancer therapy. Here we discuss the physiopathological role of epidermal Bcl-2 family members, their implications in skin carcinogenesis and as potential targets in cancer therapy. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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页码：1 / 13
页数：13
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