Three new DP alleles identified in a study of 800 unrelated bone marrow donor-recipient pairs

被引：2
|
作者：
Grams, SE
Wu, J
Noreen, HJ
Mangaccat, J
Cognato, MA
Johnson, S
Segall, M
Williams, TM
Begovich, AB
机构：
[1] Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA
[2] Roche Mol Syst, Dept Human Genet, Alameda, CA USA
[3] Univ New Mexico, Dept Pathol, Albuquerque, NM 87131 USA
[4] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
[5] Fairview Univ, Med Ctr, Minneapolis, MN USA
来源：
TISSUE ANTIGENS | 2001年 / 58卷 / 04期
关键词：
bone marrow transplantation; HLA class II; HLA-DPA1; HLA-DPB1; polymorphism; sequence motif;
D O I：
10.1034/j.1399-0039.2001.580410.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
HLA-DP genotyping of 800 unrelated donor-recipient pairs in phase 5 of a retrospective analysis of unrelated bone marrow transplantation, sponsored by the National Marrow Donor Program (NMDP(R)), has identified two new DPB1 alleles (DPB1*8701 and DBP1*8801) and one new DPA1 (DPA1*0108) allele, Sequencing confirmed that all three of the-se new alleles represent novel combinations of previously described sequence motifs, rein. forcing the notion that "gene conversion.like" events play an important rule in generating HLA allelic diversity. The identification of these new alleles brings the total number of DPA1 alleles to 20 and the total number of DPB1 alleles to 94.
引用
收藏
页码：272 / 275
页数：4
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