In Vitro Susceptibility of Aspergillus fumigatus to Isavuconazole: Correlation with Itraconazole, Voriconazole, and Posaconazole

被引：58
|
作者：
Gregson, Lea [1 ]
Goodwin, Joanne [1 ]
Johnson, Adam [1 ]
McEntee, Laura [1 ]
Moore, Caroline B. [2 ,3 ]
Richardson, Malcolm [2 ,3 ]
Hope, William W. [1 ]
Howard, Susan J. [1 ]
机构：
[1] Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool L69 3BX, Merseyside, England
[2] Univ Manchester, Univ S Manchester Hosp, Manchester Acad Hlth Sci Ctr, Sch Translat Med, Manchester, Lancs, England
[3] Univ S Manchester Hosp, Mycol Reference Ctr Manchester, Manchester M20 8LR, Lancs, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 11期
基金：
美国国家卫生研究院;
关键词：
AZOLE RESISTANCE; PATIENT; BAL4815;
D O I：
10.1128/AAC.01141-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Triazoles are first-line agents for treating aspergillosis. The prevalence of azole resistance in Aspergillus fumigatus is increasing, and cross-resistance is a growing concern. In this study, the susceptibilities of 40 A. fumigatus clinical isolates were tested by using the CLSI method with amphotericin B, itraconazole, voriconazole, posaconazole, and the new triazole isavuconazole. Isavuconazole MICs were higher in strains with reduced susceptibilities to other triazoles, mirroring changes in voriconazole susceptibility. Isavuconazole MICs differed depending on the Cyp51A substitution.
引用
收藏
页码：5778 / 5780
页数：3
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