The calcium-sensing receptor in taste tissue

被引：66
|
作者：
Gabriel, Ana San [1 ]
Uneyama, Hisayuki [1 ]
Maekawa, Takarni [1 ]
Torii, Kunio [1 ]
机构：
[1] Ajinomoto Co Inc, Inst Life Sci, Kawasaki, Kanagawa 2108681, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 378卷 / 03期
关键词：
Calcium; G protein-coupled receptor; Taste; TaqMan PCR; Extracellular calcium receptor; Amino acids; Gustducin; PLC beta; Neural cell adhesion molecule; EXTRACELLULAR CA2+-SENSING RECEPTORS; CA2+ OSCILLATIONS; CELLS; EXPRESSION; MOUSE; RESPONSES; STOMACH; CULTURE; CLONING; BRAIN;
D O I：
10.1016/j.bbrc.2008.11.060
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Calcium is an essential nutrient that induces a distinctive taste quality, but the sensing mechanism of calcium in the tongue is poorly understood. A recent study linked calcium to T1R3 receptor. Here, we propose another system for calcium taste involving the extracellular calcium-sensing receptor (CaSR). This G protein-coupled receptor that responds to calcium and magnesium cations is involved in calcium homeostasis regulating parathyroid and kidney functions. In this study, CaSR was found in isolated taste buds from rats and mice. It was expressed in a subset of cells in circumvallate and foliate papillae, with fewer cells in the fungiform papillae. This is the first evidence in mammals that locates CaSR in gustatory tissue and provides the basis for better understanding not Only Calcium taste but also the taste of multiple CaSR agonists. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：414 / 418
页数：5
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