Targeting Multiplicity: The Key Factor for Anti-Cancer Nanoparticles

被引:11
|
作者
Gary-Bobo, M. [1 ,4 ]
Vaillant, O. [1 ]
Maynadier, M. [1 ]
Basile, I. [1 ]
Gallud, A. [1 ]
El Cheikh, K. [1 ]
Bouffard, E. [1 ]
Morere, A. [1 ,4 ]
Rebillard, X. [1 ,2 ]
Puche, P. [1 ,3 ]
Nirde, P. [1 ]
Garcia, M. [1 ,4 ]
机构
[1] CNRS, Inst Biomol Max Mousseron, UMR 5247, UM1,UM2, F-34093 Montpellier 05, France
[2] Clin Mutualiste Beau Soleil, Serv Urol, F-34070 Montpellier, France
[3] Hop St Eloi, Serv Medicochirurg Malad Appareil Digestif & Tran, Montpellier 5, France
[4] NanoMedSyn, F-34093 Montpellier 05, France
关键词
Cancer; multiple targeting; nanoparticles; non-invasive therapies; MESOPOROUS SILICA NANOPARTICLES; 2-PHOTON PHOTODYNAMIC THERAPY; IRON-OXIDE NANOPARTICLES; CARBONIC-ANHYDRASE-IX; BREAST-CANCER CELLS; DRUG-DELIVERY; POLYMERIC NANOPARTICLES; CONTRAST AGENT; ENHANCED MRI; BLOOD-FLOW;
D O I
10.2174/0929867311320150002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this mini-review, we focus on different strategies to bring nanotools specifically to cancer cells. We discuss about a better targeting of tumor, combining the characteristics of tumor environment, the increase in nanoparticles life time, the biomarkers overexpressed on cancer cells and different physical methods for non invasive therapies. Here we detail the necessity of a synergy between passive and active targeting for an actual specificity of cancer cells.
引用
收藏
页码:1946 / 1955
页数:10
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