Targeting Phosphatidylserine in Anti-Cancer Therapy

被引：31

作者：

Kenis, Heidi ^{[1
]}

Reutelingsperger, Chris ^{[1
]}

机构：

[1] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Biochem, NL-6200 MD Maastricht, Netherlands

来源：

CURRENT PHARMACEUTICAL DESIGN | 2009年 / 15卷 / 23期

关键词：

PLASMA-MEMBRANE PHOSPHATIDYLSERINE; FLOW-CYTOMETRIC DETECTION; APOPTOTIC T-LYMPHOCYTES; TUMOR BLOOD-VESSELS; IN-VIVO DETECTION; ANNEXIN-V; ANIONIC PHOSPHOLIPIDS; MONOCLONAL-ANTIBODY; CELL-DEATH; AMINOPHOSPHOLIPID TRANSLOCASE;

D O I：

10.2174/138161209788923903

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Targeted delivery of cytotoxic agents limits the severe toxic side-effects of anti-cancer drugs on healthy tissues. Annexin A5 is a well explored probe to target phosphatidylserine (PS)-expressing cells in vivo. Our novel understanding of the cellular and molecular mechanism of annexin A5 as a cell-entry agent and the finding that PS is expressed on living tumour as well as endothelial cells in the tumour vasculature, will allow the development of lead compounds for anticancer therapy.

引用

页码：2719 / 2723

页数：5

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