An efficient synthesis of new 2-pyronyl-1,5-benzodiazepine derivatives

被引：0

作者：

Fodili, M

Amari, M

Kolli, B

Robert, A

Baudy-Floc'h, M

Le Grel, P

机构：

[1] Univ Rennes 1, Grp Synth & Electrosynth Organ, UMR CNRS 6510, F-35042 Rennes, France

[2] Univ Sci & Technol, Inst Chim, Bab Ezzouar, Alger, Algeria

来源：

SYNTHESIS-STUTTGART | 1999年 / 05期

关键词：

dehydroacetic acid; orthophenylenediamine; aromatic aldehydes; acetal; pyronyl side chain; 1,5-benzodiazepines;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 3,4-dihydro-2-pyronyl-1,5-benzodiazepines 4 was prepared by the reaction of DHA (dehydroacetic acid), o-PDA (orthophenylenediamine) and aromatic aldehydes in the presence of a catalytic amount of TFA (trifluoroacetic acid). 2-Pyronyl-1,5-benzodiazepines 6 in turn were synthesised from DHA, o-PDA and acetal [dimethyl formamide-dimethyl acetal (DMF-DMA) or dimethyl acetamide-dimethyl acetal (DMA-DMA)] under basic catalysis.

引用

页码：811 / 814

页数：4

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