An efficient synthesis of new 2-pyronyl-1,5-benzodiazepine derivatives

被引：0
|
作者：
Fodili, M
Amari, M
Kolli, B
Robert, A
Baudy-Floc'h, M
Le Grel, P
机构：
[1] Univ Rennes 1, Grp Synth & Electrosynth Organ, UMR CNRS 6510, F-35042 Rennes, France
[2] Univ Sci & Technol, Inst Chim, Bab Ezzouar, Alger, Algeria
来源：
SYNTHESIS-STUTTGART | 1999年 / 05期
关键词：
dehydroacetic acid; orthophenylenediamine; aromatic aldehydes; acetal; pyronyl side chain; 1,5-benzodiazepines;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 3,4-dihydro-2-pyronyl-1,5-benzodiazepines 4 was prepared by the reaction of DHA (dehydroacetic acid), o-PDA (orthophenylenediamine) and aromatic aldehydes in the presence of a catalytic amount of TFA (trifluoroacetic acid). 2-Pyronyl-1,5-benzodiazepines 6 in turn were synthesised from DHA, o-PDA and acetal [dimethyl formamide-dimethyl acetal (DMF-DMA) or dimethyl acetamide-dimethyl acetal (DMA-DMA)] under basic catalysis.
引用
收藏
页码：811 / 814
页数：4
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