Pathogenesis of Atopic Dermatitis: Current Paradigm

被引：1

作者：

Furue, Masutaka ^{[1
,2
,3
]}

Ulzii, Dugarmaa ^{[1
]}

Vu, Yen Hai ^{[1
]}

Tsuji, Gaku ^{[1
]}

Kido-Nakahara, Makiko ^{[1
]}

Nakahara, Takeshi ^{[1
,2
]}

机构：

[1] Kyushu Univ, Fac Med Sci, Dept Dermatol, Fukuoka, Fukuoka, Japan

[2] Kyushu Univ, Fac Med Sci, Dept Dermatol, Div Skin Surface Sensing, Fukuoka, Fukuoka, Japan

[3] Kyushu Univ Hosp, Res & Clin Ctr Yusho & Dioxin, Fukuoka, Fukuoka, Japan

来源：

IRANIAN JOURNAL OF IMMUNOLOGY | 2019年 / 16卷 / 02期

关键词：

Atopic Dermatitis; IL-4; IL-13; IL-31; OX40; ACTIVATION-REGULATED CHEMOKINE; MACROPHAGE-DERIVED CHEMOKINE; DENDRITIC CELLS; SKIN BARRIER; FILAGGRIN EXPRESSION; EPITHELIAL-CELLS; RECIPROCAL REGULATION; FAMILY-MEMBERS; UP-REGULATION; DOUBLE-BLIND;

D O I：

10.22034/iji.2019.80253

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles in atopic inflammation. The expression of IL-4 and IL-13 as well as type 2 chemokines such as CCL17, CCL22 and CCL26 is increased in the lesional skin of AD. In addition, IL-4 and IL-13 down-regulate the expression of filaggrin in keratinocytes and exacerbate epidermal barrier dysfunction. Keratinocytes in barrier-disrupted epidermis produce large amounts of thymic stromal lymphopoietin, IL-25 and IL-33, conducing to type 2 immune deviation via OX40L/0X40 signaling. IL-31, produced by type 2 T cells, is a cardinal pruritogenic cytokine. IL-4 and IL-13 also amplify the IL-31-mediated sensory nerve signal. These molecules are particularly important targets for future drug development for AD.

引用

页码：97 / 107

页数：11

共 50 条

[21] ATOPIC DERMATITIS - A DISCUSSION OF ITS PATHOGENESIS
STRAUSS, JS
KLIGMAN, AM
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1957, 256 (21): : 1002 - 1003
[22] Update on the Pathogenesis and Therapy of Atopic Dermatitis
Li, Huaguo
Zhang, Zhen
Zhang, Hui
Guo, Yifeng
Yao, Zhirong
[J]. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2021, 61 (03) : 324 - 338
[23] Food sensitivity and the pathogenesis of atopic dermatitis
Sampson, HA
[J]. JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1997, 90 : 2 - 8
[24] Atopic Dermatitis: Update on Pathogenesis and Comorbidities
Silverberg, Jonathan I.
Silverberg, Nanette B.
[J]. CURRENT DERMATOLOGY REPORTS, 2012, 1 (04) : 168 - 178
[25] Recent Improvements in the Pathogenesis of Atopic Dermatitis
Akan, Aysegul
Misirlioglu, Emine Dibek
Kocabas, Can Naci
[J]. GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS, 2015, 13 (03): : 194 - 200
[26] Genetic and Immunological Pathogenesis of Atopic Dermatitis
Schuler, Charles F.
Tsoi, Lam C.
Billi, Allison C.
Harms, Paul W.
Weidinger, Stephan
Gudjonsson, Johann E.
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2024, 144 (05) : 954 - 968
[27] The contribution of keratinocytes to the pathogenesis of atopic dermatitis
Pastore, S
Mascia, F
Girolomoni, G
[J]. EUROPEAN JOURNAL OF DERMATOLOGY, 2006, 16 (02) : 125 - 131
[28] PATHOGENESIS AND MANAGEMENT OF ATOPIC-DERMATITIS
FRIEDMANN, PS
TAN, BB
MUSABA, E
STRICKLAND, I
[J]. CLINICAL AND EXPERIMENTAL ALLERGY, 1995, 25 (09): : 799 - 806
[29] Advances in the pathogenesis and treatment of atopic dermatitis
Luger, T. A.
[J]. AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2012, 53 : 18 - 18
[30] The role of allergy in the pathogenesis of atopic dermatitis
LangeveldWildschut, A
BruijnzeelKoomen, C
[J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1997, 36 (02) : 280 - 281

← 1 2 3 4 5 →