Adalimumab-Induced Epstein-Barr Virus-Related Lymphoproliferative Disorder on FDG PET/CT

被引：0
|
作者：
Ward, John [1 ]
Noy, Ariela [2 ]
Ulaner, Gary [3 ]
Riedl, Christopher [3 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Southampton, Hants, England
[2] Mem Sloan Kettering Canc Ctr, Dept Med Oncol, 1275 York Ave, New York, NY 10021 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Nucl Med, 1275 York Ave, New York, NY 10065 USA
来源：
CLINICAL NUCLEAR MEDICINE | 2018年 / 43卷 / 05期
关键词：
F-18-FDG PET; CT; adalimumab; Epstein Barr virus-related lymphoproliferative disorder;
D O I：
10.1097/RLU.0000000000002054
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Adalimumab is a fully human chimeric tumor necrosis factor inhibitor used to treat immune-mediated disorders such as psoriatic arthritis. We present a 51-year-old woman with psoriatic arthritis on methotrexate and infliximab for 12 years. Adalimumab replaced infliximab because of worsening symptoms. Following 3 doses administered 1 week apart, rapidly enlarging cervical lymph nodes developed. Biopsy revealed Epstein-Barr virus-related polymorphic lymphoproliferative disorder. F-18-FDG PET/CT demonstrated widespread hypermetabolic lymphadenopathy; follow-up at 5 weeks off adalimumab revealed almost complete resolution of this adenopathy. This is most consistent with Epstein-Barr virus-related lymphoproliferative disorder secondary to tumor necrosis factor inhibition.
引用
收藏
页码：344 / 345
页数：2
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