Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.

被引：14

作者：

Hahn, Dongyup ^{[1
]}

Won, Dong Hwan ^{[1
]}

Mun, Bora ^{[1
]}

Kim, Hiyoung ^{[1
]}

Han, Chulkyeong ^{[1
]}

Wang, Weihong ^{[1
]}

Chun, Taeho ^{[1
]}

Park, Sunhee ^{[1
]}

Yoon, Dajeong ^{[1
]}

Choi, Hyukjae ^{[2
]}

Nam, Sang-Jip ^{[3
]}

Ekins, Merrick ^{[4
]}

Chin, Jungwook ^{[1
,5
]}

Kang, Heonjoong ^{[1
,5
]}

机构：

[1] Seoul Natl Univ, Sch Earth & Environm Sci, Ctr Marine Nat Prod & Drug Discovery, Seoul 151747, South Korea

[2] Yeungnam Univ, Coll Pharm, Gyongsan 712749, South Korea

[3] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea

[4] Queensland Museum, S Bank, Qld 4101, Australia

[5] Seoul Natl Univ, Res Inst Oceanog, Seoul 151747, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 08期

关键词：

Psammocinia sp; Sesterterpenoid; Scalarane; Cytotoxicity; Pancreatic cancer cell lines; Renal cancer cell lines; HYRTIOS-ERECTA; HEMIASTERLIN; NUDIBRANCHS; DEFENSE; E7974;

D O I：

10.1016/j.bmcl.2013.02.061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 mu M. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2336 / 2339

页数：4

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