Enantioselective Synthesis of Carbo- and Heterocycles through a CuH-Catalyzed Hydroalkylation Approach

被引：104

作者：

Wang, Yi-Ming ^{[1
]}

Bruno, Nicholas C. ^{[1
]}

Placeres, Angel L. ^{[1
]}

Zhu, Shaolin ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 33期

基金：

美国国家卫生研究院;

关键词：

C BOND FORMATION; ANTI-MARKOVNIKOV HYDROALKYLATION; ASYMMETRIC-SYNTHESIS; COPPER(I)-CATALYZED REACTION; VERSATILE CATALYSTS; ALKYL-GROUPS; ALKENES; HYDROAMINATION; ALCOHOLS; OLEFINS;

D O I：

10.1021/jacs.5b07061

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantios elective, intramolecular hydro-alkylation of halide-tethered styrenes has been achieved through a copper hydride-catalyzed process. This approach allowed for the synthesis of enantioenriched cydobutanes, cyclopentanes, indanes, and six-membered N- and O-heterocycles. This protocol was applied to the synthesis of the commercial serotonin reuptake inhibitor (-)-paroxetine.

引用

页码：10524 / 10527

页数：4

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