Altering Tissue Glycan Patterns Improves the Transduction Profile of AAV9 Vectors

被引:0
|
作者
Shen, Shen [1 ]
Sun, Junjiang [1 ]
Hirsch, Matthew [1 ]
Chavala, Sai [2 ]
Monahan, Paul [1 ]
Asokan, Aravind [1 ]
机构
[1] Univ N Carolina, Gene Therapy Ctr, Chapel Hill, NC USA
[2] Univ N Carolina, Dept Ophthalmol, Chapel Hill, NC USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
527
引用
收藏
页码:S203 / S203
页数:1
相关论文
共 50 条
  • [31] AAV9 Transduction Is Similar in Adult and Aged Mouse Brains Following Intraparenchymal Injection
    Gombash, Sara E.
    Fitzgerald, Julie A.
    Cowley, Christopher J.
    Neides, Mitchell G.
    Armstrong, Emily
    Norden, Diana M.
    Godbout, Jonathan P.
    Foust, Kevin D.
    MOLECULAR THERAPY, 2016, 24 : S245 - S245
  • [32] Tyrosine Mutation in AAV9 Capsid Improves Gene Transfer to the Mouse Lung
    Martini, Sabrina V.
    Silva, Adriana L.
    Ferreira, Debora
    Rabelo, Rafael
    Ornellas, Felipe M.
    Gomes, Karina
    Rocco, Patricia R. M.
    Petrs-Silva, Hilda
    Morales, Marcelo M.
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2016, 39 (02) : 544 - 553
  • [33] Intrathecal delivery of AAV9 vectors to model and rescue a large animal model of SMA
    Duque, S.
    Porensky, P.
    William, D. A.
    Odermatt, P.
    Nlend, R. Nlend
    Bevan, A. K.
    Foust, K.
    Braun, L.
    Schmelzer, L.
    Schumperli, D.
    Kaspar, B. K.
    Burghes, A. H. M.
    NEUROMUSCULAR DISORDERS, 2013, 23 (9-10) : 797 - 797
  • [34] Delivery of therapeutic AAV9 vectors via cisterna magna to treat neurological disorders
    Marchi, Paolo M.
    Marrone, Lara
    Azzouz, Mimoun
    TRENDS IN MOLECULAR MEDICINE, 2022, 28 (01) : 79 - 80
  • [35] AAV9 Improves Lysosomal Organization and Diaphragmatic Contractile Function in Pompe Disease
    Todd, A. Gary
    Ahn, Bumsoo
    McElroy, Jessica A.
    Fuller, David D.
    Byrne, Barry J.
    Ferreira, Leonardo F.
    Falk, Darin J.
    MOLECULAR THERAPY, 2014, 22 : S159 - S159
  • [36] Engineering Liver-detargeted AAV9 Vectors for Cardiac and Musculoskeletal Gene Transfer
    Pulicherla, Nagesh
    Shen, Shen
    Yadav, Swati
    Debbink, Kari
    Govindasamy, Lakshmanan
    Agbandje-McKenna, Mavis
    Asokan, Aravind
    MOLECULAR THERAPY, 2011, 19 (06) : 1070 - 1078
  • [37] Efficient in vivo gene transfer to murine renal cells using AAV9 vectors
    Konkalmatt, Prasad
    Asico, Laureano
    Feranil, Jun
    Jose, Pedro
    Armando, Ines
    FASEB JOURNAL, 2014, 28 (01):
  • [38] Intrapleural Administration of AAV9 Improves Neural and Cardiorespiratory Function in Pompe Disease
    Falk, Darin J.
    Mah, Cathryn S.
    Soustek, Meghan S.
    Lee, Kun-Ze
    ElMallah, Mai K.
    Cloutier, Denise A.
    Fuller, David D.
    Byrne, Barry J.
    MOLECULAR THERAPY, 2013, 21 (09) : 1661 - 1667
  • [39] Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs
    Federici, T.
    Taub, J. S.
    Baum, G. R.
    Gray, S. J.
    Grieger, J. C.
    Matthews, K. A.
    Handy, C. R.
    Passini, M. A.
    Samulski, R. J.
    Boulis, N. M.
    GENE THERAPY, 2012, 19 (08) : 852 - 859
  • [40] Sildenafil increases AAV9 transduction after a systemic administration and enhances AAV9-dystrophin therapeutic effect in mdx mice
    Zhou, Kaiyi
    Yuan, Meng
    Sun, Jiabao
    Zhang, Feixu
    Zong, Xiaoying
    Li, Zhanao
    Tang, Dingyue
    Zhou, Lichen
    Zheng, Jing
    Xiao, Xiao
    Wu, Xia
    GENE THERAPY, 2024, 31 (1-2) : 19 - 30