Sulfate Conjugates Are Urinary Markers of Inhalation Exposure to 4-Chlorobiphenyl (PCB3)

被引：19

作者：

Dhakal, Kiran

Adamcakova-Dodd, Andrea

Lehmler, Hans-Joachim

Thorne, Peter S.

Robertson, Larry W. ^{[1
]}

机构：

[1] Univ Iowa, Interdisciplinary Grad Program Human Toxicol, Iowa City, IA 52242 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2013年 / 26卷 / 06期

关键词：

HYDROXYLATED POLYCHLORINATED-BIPHENYLS; METABOLITES; INHIBITORS; 3,3'-DICHLOROBIPHENYL; SULFOTRANSFERASE; IDENTIFICATION; ELIMINATION; CONGENERS; SERUM; AIR;

D O I：

10.1021/tx4001539

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

PCBs are contaminants in the air of older buildings and cities, which raises the concern of inhalation exposure. No reliable biomarker of such exposure is available. We exposed rats to air containing 2 mg/m(3) PCB3 via nose-only inhalation for 2 h, collected urine, and analyzed it by LC/MS. Each rat inhaled an estimated dose of 35 mu g PCB3, and excreted 27 +/- 2% of it as sulfates within 24 h. Peak excretion occurred within 6 h. PCB sulfates were stable in urine for at least three days at room temperature without chemical preservatives. These data support the use of PCB sulfate conjugates as suitable urinary biomarkers of PCB3 and other airborne PCBs.

引用

页码：853 / 855

页数：3

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