Design, synthesis, and biological evaluation of amide derivatives of imidazo[2,1-b][1,3,4]thiadiazole as anticancer agents

被引：13
|
作者：
Sridhar, Gattu [1 ,2 ]
Palle, Sadanandam [3 ]
Vantikommu, Jyothi [3 ]
Gangarapu, Kiran [4 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Organ & Biomol Chem Div, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India
[2] Kakatiya Inst Technol & Sci, Dept Chem, Warangal, Andhra Pradesh, India
[3] Jawaharlal Nehru Technol Univ, Inst Sci & Technol, Ctr Chem Sci & Technol, Hyderabad, Telangana, India
[4] Anurag Grp Inst, Sch Pharm, Medchal, India
来源：
SYNTHETIC COMMUNICATIONS | 2020年 / 50卷 / 21期
关键词：
Acetazolamide; anticancer properties; imidazo[2; 1-b][1; 3; 4]thiadiazole; levamisole; 1; 4-thiadiazole; ANTIBACTERIAL ACTIVITY; ANTICONVULSANT; POTENT;
D O I：
10.1080/00397911.2020.1797814
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new library of amide derivatives of imidazo[2,1-b][1,3,4]thiadiazoles (11a-j) have designed and synthesized and their structures determined by(1)H NMR,C-13 NMR, mass and HRMS spectral data. Further, all these compounds were evaluated for their anticancer potentials on a panel of cancer cell lines like MCF-7, MDA MB-231 (breast carcinoma), A549 (lung carcinoma) and DU-145 (prostate carcinoma) by using MTT assay and obtained IC(50)values were compared with well-known chemotherapeutic agent etoposide. Among them, compounds11b-eand11ishowed potent anticancer activity against the entire cancer cell lines than the chemotherapeutic drug. Particularly, one compound11bdemonstrated prominent activity.
引用
收藏
页码：3221 / 3233
页数：13
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